Evidence map›Paper›PMID 28785144›Full record

ArticleWorld journal of gastroenterology2017

Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease.

Zhenwu Lin, Zhong Wang, John P Hegarty, Tony R Lin, Yunhua Wang, Sue Deiling, Rongling Wu, Neal J Thomas, Joanna Floros

Open access · bronzeAbstract read
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  8. Biomedical reports · 2024
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  12. The effect ofBiology of sport · 2022
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  17. Review
  18. [Association of interleukin-10 gene polymorphism with enterovirus 71 infection in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019
    Article
  19. [Construction of rat interleukin-10 adenoviral vector and its expression in bone marrow mesenchymal stem cells].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Zhenwu LinZhenwu Lin, Yunhua Wang, Neal J Thomas, Joanna Floros, CHILD Research, Department of Pediatrics, the Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
Zhong WangZhenwu Lin, Yunhua Wang, Neal J Thomas, Joanna Floros, CHILD Research, Department of Pediatrics, the Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
John P HegartyZhenwu Lin, Yunhua Wang, Neal J Thomas, Joanna Floros, CHILD Research, Department of Pediatrics, the Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
Tony R LinZhenwu Lin, Yunhua Wang, Neal J Thomas, Joanna Floros, CHILD Research, Department of Pediatrics, the Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
Yunhua WangZhenwu Lin, Yunhua Wang, Neal J Thomas, Joanna Floros, CHILD Research, Department of Pediatrics, the Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
Sue DeilingZhenwu Lin, Yunhua Wang, Neal J Thomas, Joanna Floros, CHILD Research, Department of Pediatrics, the Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
Rongling WuZhenwu Lin, Yunhua Wang, Neal J Thomas, Joanna Floros, CHILD Research, Department of Pediatrics, the Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
Neal J ThomasZhenwu Lin, Yunhua Wang, Neal J Thomas, Joanna Floros, CHILD Research, Department of Pediatrics, the Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
Joanna FlorosZhenwu Lin, Yunhua Wang, Neal J Thomas, Joanna Floros, CHILD Research, Department of Pediatrics, the Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
Pennsylvania State University · USCancer Research And Biostatistics · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo study the genetic association and epistatic interaction of the interleukin (IL)-10 and IL-10/STAT3 pathways in pediatric inflammatory bowel disease (IBD).

methodsA total of 159 pediatric inflammatory IBD patients (Crohn's disease,

resultsThe results showed that IL-10 rs304496 was associated with pediatric IBD (

conclusionThese results indicate that both the

Indexed as

Epistasis, GeneticGenetic Predisposition to DiseaseAdolescentChildColitis, UlcerativeComputer SimulationCrohn DiseaseFemaleGenetic Association StudiesGenotypeHeme Oxygenase-1HumansInterleukin-10Interleukin-10 Receptor alpha SubunitInterleukin-10 Receptor beta SubunitMaleHeme Oxygenase-1HMOX1 protein, humanIL10 protein, humanIL10RB protein, humanInterleukin-10Interleukin-10 Receptor alpha SubunitInterleukin-10 Receptor beta SubunitSTAT3 protein, humanSTAT3 Transcription FactorEpistatic interactionHO1IL10-STAT3 pathwayInterleukin-10Pediatric inflammatory bowel diseaseSingle nucleotide polymorphism

Identifiers

PMID28785144
PMCPMC5526760
OpenAlexW2739332150

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.