ArticleScientific reports2017
Shannon entropy of brain functional complex networks under the influence of the psychedelic Ayahuasca.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 4 of them syntheses that pooled it.
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Who cites it
61 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Neuroscience of Religious and Spiritual Practices: A Systematic Review of Neurotheological Evidence.Brain and behavior · 2026Pooled it
- The Use of Psychedelics in the Treatment of Adult ADHD: A Systematic and Mechanistic Review.International journal of molecular sciences · 2026Pooled it
- What fMRI studies say about the nature of the psychedelic effect: a scoping review.Frontiers in neuroscience · 2025Pooled it
- Default Mode Network Modulation by Psychedelics: A Systematic Review.The international journal of neuropsychopharmacology · 2023Pooled it
- Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- The entropic brain today.Brain : a journal of neurology · 2026Review
- Multi-metric evaluations of acute psychedelic effects on fMRI brain entropy.Nature communications · 2026Article
- Ayahuasca and Its Main ComponentBiomedicines · 2026Review
- When Randomness Becomes Rigid: Dynamic Connectivity Entropy and Symptom-Linked Network Dysfunction in Schizophrenia.bioRxiv : the preprint server for biology · 2026Article
- Short- and long-term modulation of rat prefrontal cortical activity following single doses of psilocybin.Molecular psychiatry · 2025Article
- Psychedelic 5-HTNature neuroscience · 2025Article
- The role of structural and functional parameters in designing pathology-specific tDCS protocols for primary progressive aphasia.Alzheimer's research & therapy · 2025Article
- Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT).Communications biology · 2025Article
- Structured Dynamics in the Algorithmic Agent.Entropy (Basel, Switzerland) · 2025Article
- A Computational Account of the Development and Evolution of Psychotic Symptoms.Biological psychiatry · 2025Review
- LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Meditation and complexity: a review and synthesis of evidence.Neuroscience of consciousness · 2025Review
- Whole brain modelling for simulating pharmacological interventions on patients with disorders of consciousness.Communications biology · 2024Article
- Neurobiological research on N,N-dimethyltryptamine (DMT) and its potentiation by monoamine oxidase (MAO) inhibition: from ayahuasca to synthetic combinations of DMT and MAO inhibitors.Cellular and molecular life sciences : CMLS · 2024Review
- Complexity organization of resting-state functional-MRI networks.Human brain mapping · 2024Article
1 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
The entropic brain hypothesis holds that the key facts concerning psychedelics are partially explained in terms of increased entropy of the brain's functional connectivity. Ayahuasca is a psychedelic beverage of Amazonian indigenous origin with legal status in Brazil in religious and scientific settings. In this context, we use tools and concepts from the theory of complex networks to analyze resting state fMRI data of the brains of human subjects under two distinct conditions: (i) under ordinary waking state and (ii) in an altered state of consciousness induced by ingestion of Ayahuasca. We report an increase in the Shannon entropy of the degree distribution of the networks subsequent to Ayahuasca ingestion. We also find increased local and decreased global network integration. Our results are broadly consistent with the entropic brain hypothesis. Finally, we discuss our findings in the context of descriptions of "mind-expansion" frequently seen in self-reports of users of psychedelic drugs.
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