ArticleScientific reports2017
Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- How are social determinants of health integrated into epigenetic research? A systematic review.Social science & medicine (1982) · 2021Pooled it
- A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches.Translational psychiatry · 2021Pooled it
- DNA methylation and brain structure and function across the life course: A systematic review.Neuroscience and biobehavioral reviews · 2020Pooled it
- The oxytocinergic system in functional neurological disorder: Preliminary testing of associations with interoception and childhood trauma.Comprehensive psychoneuroendocrinology · 2026Article
- An epigenetic framework for understanding contextual influences on neural and socio-emotional development: Narrative review and case-study of the oxytocin receptor.Developmental cognitive neuroscience · 2026Review
- Experiences in close relationships, interpersonal trust and OXTR expression in individuals with childhood maltreatment.Borderline personality disorder and emotion dysregulation · 2026Article
- Parental behavior, adult attachment, and DNA methylation of the MT2 oxytocin receptor gene region - The moderating role of neuroticism.PloS one · 2026Article
- Early Life Mild Adversity Affects in a Sexually Dimorphic Way the Oxytocinergic System Reducing Close Social Interaction in Adult Male Rats.Journal of neurochemistry · 2025Article
- The role of stress proliferation in linking childhood stressors to accelerated biological aging.Social science & medicine (1982) · 2025Article
- Internalizing and Externalizing Traits During Adolescence: Using Epigenetics and Perinatal Risks to Differentiate Clusters of Symptoms.Biomolecules · 2025Article
- Functional characterization of OXTR-associated enhancers.Human molecular genetics · 2025Article
- The impact of the early environment on oxytocin receptor epigenetics and potential therapeutic implications.Pediatric research · 2025Review
- Salivary oxytocin and amygdalar alterations in functional neurological disorders.Brain communications · 2025Article
- Epigenetic regulation of the oxytocin system as an indicator of adaptation to over-controlling parenting and psychosocial functioning in adulthood.Psychoneuroendocrinology · 2024Article
- Grandmotherhood is associated with reduced OXTR DNA methylation.Psychoneuroendocrinology · 2024Article
- [Research progress on the mechanism of the impact of maternal childhood trauma on intergenerational transmission].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- The DNA methylation landscape of the human oxytocin receptor gene (OXTR): data-driven clusters and their relation to gene expression and childhood adversity.Translational psychiatry · 2023Article
- Review
- Sex matters: The impact of oxytocin on healthy conditions and psychiatric disorders.Comprehensive psychoneuroendocrinology · 2023Article
- Oxytocin receptor DNA methylation is associated with exogenous oxytocin needs during parturition and postpartum hemorrhage.Communications medicine · 2023Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
Abstract
Recent models propose deoxyribonucleic acid methylation of key neuro-regulatory genes as a molecular mechanism underlying the increased risk of mental disorder associated with early life adversity (ELA). The goal of this study was to examine the association of ELA with oxytocin receptor gene (OXTR) methylation among young adults. Drawing from a 21-year longitudinal cohort, we compared adulthood OXTR methylation frequency of 46 adults (23 males and 23 females) selected for high or low ELA exposure based on childhood socioeconomic status and exposure to physical and sexual abuse during childhood and adolescence. Associations between OXTR methylation and teacher-rated childhood trajectories of anxiousness were also assessed. ELA exposure was associated with one significant CpG site in the first intron among females, but not among males. Similarly, childhood trajectories of anxiousness were related to one significant CpG site within the promoter region among females, but not among males. This study suggests that females might be more sensitive to the impact of ELA on OXTR methylation than males.
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