SynthesisScientific reports2017
The Risk Factors and Neonatal outcomes of Isolated Single Umbilical Artery in Singleton Pregnancy: A Meta-analysis.
Synthesis in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Timing of milk expression following delivery in mothers delivering preterm very low birth weight infants: a randomized trial.Journal of perinatology : official journal of the California Perinatal Association · 2020Trial
- Intrapartum CTG characteristics associated with isolated single umbilical artery in term fetuses: A matched case-control study.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Risk factors and adverse fetal outcomes in umbilical artery thrombosis: a comparison with single umbilical artery.BMC pregnancy and childbirth · 2025Article
- Risks of Renal Anomalies and Urinary Tract Infections in Neonates With Single Umbilical Artery.Cureus · 2024Article
- Diagnosis of single umbilical artery and risk of foetal congenital malformations by prenatal ultrasound: a retrospective study.BMC pregnancy and childbirth · 2024Article
- Analysis of single umbilical artery with concurrent congenital anomaly: Is it a risk factor for poor prognosis? A cross-sectional study.International journal of reproductive biomedicine · 2024Article
- Prenatal Diagnosis of Isolated Single Umbilical Artery: Incidence, Risk Factors and Impact on Pregnancy Outcomes.Medicina (Kaunas, Lithuania) · 2023Article
- Prenatal diagnosis of ultrasound soft markers in a single medical center of mainland China.Molecular cytogenetics · 2023Article
- Human Umbilical Cord: Information Mine in Sex-Specific Medicine.Life (Basel, Switzerland) · 2021Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current meta-analysis aims to evaluate the risk factors and neonatal outcomes of isolated Single Umbilical Artery (iSUA) in singleton pregnancy. Standard Mean Difference (SMD) or Weighted Mean Difference (WMD) was pooled for the maternal age, gravidity and parity, neonate birth weight and Apgar score one and five minutes after birth. We also pooled the odds ratios (ORs) at 95% confidence intervals (CIs) for maternal smoking status, the rate of neonate delivery before 37 or 34 weeks, Cesarean section (CS), the rate of being admitted to neonatal intensive care unit (NICU) and the serious adverse neonate outcome. Results show that maternal primigravidity [OR: -0.082, CI (-0.152, -0.011), p = 0.023] and female sex of the neonate [OR: 0.805, CI (0.673, 0.963), p = 0.017] were associated with higher risks of iSUA. As compared to normal neonates, the neonates with iSUA had lower birth weight, worse Apgar score, increased risk of delivery before the normal gestational age, increased rate of CS due to fetal distress, increased rate of admission to NICU and prolonged NICU stay. However, no difference in neonatal mortality was observed. Maternal primigravidity and female neonate might associate with increased risk of iSUA. Identification of iSUA is of great importance for prenatal diagnosis and may improve neonatal outcomes.
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