Evidence map›Paper›PMID 28784989›Full record

ArticleScientific reports2017

Optimization of Magneto-thermally Controlled Release Kinetics by Tuning of Magnetoliposome Composition and Structure.

Behzad Shirmardi Shaghasemi, Mudassar Mumtaz Virk, Erik Reimhult

Erratum issuedAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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  16. Magnetic Nanoparticles as MRI Contrast Agents.Topics in current chemistry (Cham) · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Behzad Shirmardi ShaghasemiInstitute for Biologically Inspired Materials, Department of Nanobiotechnology, University of Natural Resources and Life Sciences, Muthgasse 11, 1190, Vienna, Austria.
Mudassar Mumtaz VirkInstitute for Biologically Inspired Materials, Department of Nanobiotechnology, University of Natural Resources and Life Sciences, Muthgasse 11, 1190, Vienna, Austria.
Erik ReimhultInstitute for Biologically Inspired Materials, Department of Nanobiotechnology, University of Natural Resources and Life Sciences, Muthgasse 11, 1190, Vienna, Austria. erik.reimhult@boku.ac.at.ORCID 0000-0003-1417-5576

Funding

European Research Council 310034
6 · The paper itself

Abstract

Stealth (PEGylated) liposomes have taken a central role in drug formulation and delivery combining efficient transport with low nonspecific interactions. Controlling rapid release at a certain location and time remains a challenge dependent on environmental factors. We demonstrate a highly efficient and scalable way to produce liposomes of any lipid composition containing homogeneously dispersed monodisperse superparamagnetic iron oxide nanoparticles in the membrane interior. We investigate the effect of lipid composition, particle concentration and magnetic field actuation on colloidal stability, magneto-thermally actuated release and passive release rates. We show that the rate and amount of encapsulated hydrophilic compound released by actuation using alternating magnetic fields can be precisely controlled from stealth liposomes with high membrane melting temperature. Extraordinarily low passive release and temperature sensitivity at body temperature makes this a promising encapsulation and external-trigger-on-demand release system. The introduced feature can be used as an add-on to existing stealth liposome drug delivery technology.

Indexed as

Delayed-Action PreparationsDrug CompoundingDrug Delivery SystemsFerric CompoundsHydrophobic and Hydrophilic InteractionsKineticsLiposomesMagnetic FieldsMagnetite NanoparticlesPolyethylene GlycolsTemperatureDelayed-Action PreparationsFerric Compoundsferric oxideLiposomesMagnetite NanoparticlesPolyethylene Glycols

Identifiers

PMID28784989
PMCPMC5547053

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.