Evidence map›Paper›PMID 28784931›Full record

ArticleInfection and immunity2017

Impairment of Hematopoietic Precursor Cell Activation during the Granulopoietic Response to Bacteremia in Mice with Chronic-Plus-Binge Alcohol Administration.

Xin Shi, Yuan-Ping Lin, Bin Gao, Ping Zhang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Alcohol abuse and disorder of granulopoiesis.Pharmacology & therapeutics · 2019
    Review
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Xin ShiDepartment of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, Ohio, USA.
Yuan-Ping LinNational Defense Medical Center, School of Pharmacy and Graduate Institute of Pharmacy, Taipei City, Taiwan, Republic of China.
Bin GaoLaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.
Ping ZhangDepartment of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, Ohio, USA pzhang@neomed.edu.
Northeast Ohio Medical University · USNational Defense Medical Center · TWNational Institute on Alcohol Abuse and Alcoholism · US

Funding

Alcohol, Septicemia and the LKS Cell ResponseR01AA019676 · NIAAA · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, PING · 2010 to 2014
$1.7M
Alcohol, hedgehog signal, and HSC dysfunction in host defense against septicemiaR01AA022816 · NIAAA · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, PING · 2014 to 2018
$1.7M
NIAAA NIH HHS R01 AA019676NIAAA NIH HHS R01 AA022816
6 · The paper itself

Abstract

Alcohol abuse impairs immune defense. To study the effect of chronic-plus-binge alcohol exposure on the granulopoietic response, acute alcohol intoxication (intraperitoneal injection of 5 g alcohol/kg body weight) was introduced to mice chronically fed on the Lieber-DeCarli low-fat liquid alcohol diet for 5 weeks. Bacteremia was induced by intravenous injection of

Indexed as

AnimalsAntigens, LyBacteremiaBinge DrinkingBone Marrow CellsCCAAT-Enhancer-Binding Protein-betaCyclin D1Disease Models, AnimalEscherichia coliEscherichia coli InfectionsEthanolGene Expression RegulationGranulocytesHematopoiesisMaleMembrane ProteinsAntigens, LyCCAAT-Enhancer-Binding Protein-betaCcnd1 protein, mouseCebpb protein, mouseCyclin D1Ethanollincosaminide O-nucleotidyltransferaseLy6a protein, mouseLy6G antigen, mouseMapk1 protein, mouseMembrane ProteinsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3NucleotidyltransferasesProto-Oncogene Proteins c-kitTlr4 protein, mouseToll-Like Receptor 4Alcoholbacteremiacell signalinggranulocytesgranulopoietic responsestem cells

Identifiers

PMID28784931
PMCPMC5649015
OpenAlexW2743391358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.