Evidence map›Paper›PMID 28784930›Full record

ArticleInfection and immunity2017

Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components.

Erin E Zwack, Eric M Feeley, Amanda R Burton, Baofeng Hu, Masahiro Yamamoto, Thirumala-Devi Kanneganti, James B Bliska, Jörn Coers, Igor E Brodsky

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Article
  3. mBio · 2023
    Article
  4. bioRxiv : the preprint server for biology · 2023
    Article
  5. Review
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  15. Review
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  17. Review
  18. Article
  19. Review
  20. Cytosolic Recognition of Microbes and Pathogens: Inflammasomes in Action.Microbiology and molecular biology reviews : MMBR · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Erin E ZwackDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Eric M FeeleyDepartments of Molecular Genetics and Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina, USA.
Amanda R BurtonDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Baofeng HuDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Masahiro YamamotoDepartment of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Thirumala-Devi KannegantiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
James B BliskaDepartment of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, New York, USA.
Jörn CoersDepartments of Molecular Genetics and Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina, USA.
Igor E BrodskyDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA ibrodsky@vet.upenn.edu.
University of Pennsylvania · USSt. Jude Children's Research Hospital · USDuke Medical Center · USDuke University Hospital · USOsaka University · JPStony Brook University · US

Funding

TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 1997 to 2026
$32.5M
Regulation of host innate and adaptive immunity by bacterial type III effectorsR01AI099222 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI BLISKA, JAMES B · 2012 to 2025
$5.9M
IRGM-driven host responses to Chlamydia trachomatis infectionsR01AI103197 · NIAID · DUKE UNIVERSITY · PI COERS, JOERN · 2013 to 2023
$4.2M
Training in bacteriologyT32AI060516 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D, ZHU, JUN · 2006 to 2015
$2.0M
Modulation of Inflammasome Activation by YersiniaR01AI103062 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E · 2013 to 2016
$1.7M
FLIM system, resonant scanner, and UV laser for 2 photon microscopeS10RR027128 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FREEDMAN, BRUCE D · 2010 to 2010
$496k
Innate immune recognition of bacterial secretion systems by GBPsR21AI122048 · NIAID · DUKE UNIVERSITY · PI COERS, JOERN · 2016 to 2017
$425k
NCRR NIH HHS S10 RR027128NIAID NIH HHS R01 AI099222NIAID NIH HHS R01 AI103062NIAID NIH HHS R01 AI103197NIAID NIH HHS R21 AI122048NIAID NIH HHS T32 AI060516NIDDK NIH HHS P30 DK050306
6 · The paper itself

Abstract

Gram-negative bacterial pathogens utilize virulence-associated secretion systems to inject, or translocate, effector proteins into host cells to manipulate cellular processes and promote bacterial replication. However, translocated bacterial products are sensed by

Indexed as

AnimalsBacterial Outer Membrane ProteinsCaspase 1Cell LineCytokinesGalectin 3GTP-Binding ProteinsInflammasomesLysosomal-Associated Membrane Protein 1MiceProtein TransportType III Secretion SystemsVirulenceYersinia pseudotuberculosisBacterial Outer Membrane ProteinsCaspase 1CytokinesGalectin 3GTP-Binding ProteinsInflammasomesLysosomal-Associated Membrane Protein 1Type III Secretion SystemsYopB protein, YersiniaYopD protein, YersiniaGBPsguanylate binding proteinsinflammasomenoncanonicaltype three secretion systemYersiniaYopD

Identifiers

PMID28784930
PMCPMC5607426
OpenAlexW2744831416

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.