ArticleBMJ case reports2017
Serotonin syndrome caused by drug to drug interaction between escitalopram and dextromethorphan.
Article in BMJ case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Drug-Induced Myoclonus: A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Adult U.S. Poison Center Exposure Case Trends Involving Nonprescription Dextromethorphan Amid the COVID-19 Pandemic: a Quasi-experimental Interrupted Time Series Study.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2026Article
- Article
- Akathisia Induced by Metoclopramide in a Pregnant Woman With Nausea and Vomiting: A Case Report.Neuropsychopharmacology reports · 2026Article
- Dextromethorphan Overdose with Refractory Status Epilepticus and Reversible Cranial Nerve Reflex Loss: A Case Report.The American journal of case reports · 2025Article
- Serotonin syndrome induced by Bromfed DM in a patient on sertraline.SAGE open medical case reports · 2025Article
- Drug-Drug Interactions of Selective Serotonin Reuptake Inhibitors: A Pharmacovigilance Study on Real-World Evidence from the EudraVigilance Database.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Administration of Intravenous Lipid Emulsion for Dextromethorphan Poisoning with Serotonin Syndrome: A Case Report.Journal of personalized medicine · 2024Article
- High doses of dextromethorphan induced shock and convulsions in a 19-year-old female: A case report.World journal of clinical cases · 2023Article
- Antipsychotic Drugs Efficacy in Dextromethorphan-Induced Psychosis.Biomedicines · 2023Review
- Solving an unusual case of acute kidney injury: Answers.Pediatric nephrology (Berlin, Germany) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 63-year-old woman with a history of long-standing depression, maintained on escitalopram, presented with altered mental status. Patient had recently been prescribed dextromethorphan-promethazine cough syrup 2 weeks prior for an upper respiratory tract infection. On admission, she was lethargic and obtunded and found to have inducible myoclonus on examination. The rest of her physical exam was unremarkable. Pertinent lab and imaging findings showed QTc prolongation on ECG, negative electroencephalogram and CT head findings, essentially normal blood tests and a negative toxicology screen. The patient was admitted to the step down unit for close observation; both escitalopram and the cough syrup were suspended and was supportively managed. Overnight the patient's mental status improved and the serial EcGs showed resolution of the prolonged QTc. Patient was discharged home without further complication.
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Registered trials
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