Evidence map›Paper›PMID 28784797›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Cytotoxic protein from the mushroom

Peilan Zhang, Kunhua Li, Guang Yang, Changqing Xia, Jane E Polston, Gengnan Li, Shiwu Li, Zhao Lin, Li-Jun Yang, Steven D Bruner and 1 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. A Comprehensive Structural and Functional Analysis ofbioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Peilan ZhangDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development, University of Florida, Gainesville, FL 32610.
Kunhua LiDepartment of Chemistry, University of Florida, Gainesville, FL 32611.ORCID 0000-0002-9139-4257
Guang YangDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development, University of Florida, Gainesville, FL 32610.
Changqing XiaDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32610.
Jane E PolstonDepartment of Plant Pathology, University of Florida, Gainesville, FL 32611.
Gengnan LiDepartment of Chemistry, University of Florida, Gainesville, FL 32611.
Shiwu LiDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32610.
Zhao LinDepartment of Periodontics, Virginia Commonwealth University, Richmond, VA 23298.
Li-Jun YangDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32610.
Steven D BrunerDepartment of Chemistry, University of Florida, Gainesville, FL 32611; bruner@chem.ufl.edu YDing@cop.ufl.edu.
Yousong DingDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development, University of Florida, Gainesville, FL 32610; bruner@chem.ufl.edu YDing@cop.ufl.edu.ORCID 0000-0001-8610-0659
University of Florida · USVirginia Commonwealth University · US

Funding

Overall Priority Score P41GM103694 · NIGMS · EMORY UNIVERSITY · PI CUMMINGS, RICHARD D · 2013 to 2018
$6.9M
Protein-Glycan Interaction Resource of the CFGR24GM098791 · NIGMS · EMORY UNIVERSITY · PI CUMMINGS, RICHARD D, PAULSON, JAMES C · 2011 to 2013
$2.6M
NIGMS NIH HHS P41 GM103694NIGMS NIH HHS R24 GM098791
6 · The paper itself

Abstract

Glycans possess significant chemical diversity; glycan binding proteins (GBPs) recognize specific glycans to translate their structures to functions in various physiological and pathological processes. Therefore, the discovery and characterization of novel GBPs and characterization of glycan-GBP interactions are significant to provide potential targets for therapeutic intervention of many diseases. Here, we report the biochemical, functional, and structural characterization of a 130-amino-acid protein, Y3, from the mushroom

Indexed as

AgaricalesAmino Acid SequenceApoptosisCell SurvivalCoprinusCrystallography, X-RayFungal ProteinsHEK293 CellsHumansJurkat CellsModels, MolecularPolysaccharidesProtein BindingProtein ConformationProtein MultimerizationSequence Homology, Amino AcidFungal ProteinsPolysaccharidesCoprinus comatuscrystal structurecytotoxicityglycan binding proteinLDNF

Identifiers

PMID28784797
PMCPMC5576819
OpenAlexW2742535650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.