ArticleProceedings of the National Academy of Sciences of the United States of America2017
Janus dendrimersomes coassembled from fluorinated, hydrogenated, and hybrid Janus dendrimers as models for cell fusion and fission.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- Biocompatible Glycopolymer-PLA Amphiphilic Hybrid Block Copolymers with Unique Self-Assembly, Uptake, and Degradation Properties.Biomacromolecules · 2024Article
- Chemical Information Processing by a Responsive Chemical System.Journal of the American Chemical Society · 2024Article
- Recent Progress of Rational Modified Nanocarriers for Cytosolic Protein Delivery.Pharmaceutics · 2023Review
- Article
- Article
- Learning the relationship between nanoscale chemical patterning and hydrophobicity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects.International journal of molecular sciences · 2022Article
- Spontaneous Formation and Fusion of Raspberry Vesicle Self-Assembled from Star Block Terpolymers in Aqueous Solution.Materials (Basel, Switzerland) · 2021Article
- Recent Advances in Interface Engineering for Electrocatalytic CONano-micro letters · 2021Review
- Identifying hydrophobic protein patches to inform protein interaction interfaces.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Probing the fluorination effect on the self-assembly characteristics,Theranostics · 2021Article
- Fluoroalkylation promotes cytosolic peptide delivery.Science advances · 2020Article
- Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Encoding biological recognition in a bicomponent cell-membrane mimic.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Dendrimersomes.Biomacromolecules · 2019Article
- Bioactive cell-like hybrids from dendrimersomes with a human cell membrane and its components.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Dendrimersomes Exhibit Lamellar-to-Sponge Phase Transitions.Langmuir : the ACS journal of surfaces and colloids · 2018Article
- The fluorination effect of fluoroamphiphiles in cytosolic protein delivery.Nature communications · 2018Article
- Microarray Analysis of Oligosaccharide-Mediated Multivalent Carbohydrate-Protein Interactions and Their Heterogeneity.Chembiochem : a European journal of chemical biology · 2018Article
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Authors and funding
11 authors.
Funding
Abstract
A three-component system of Janus dendrimers (JDs) including hydrogenated, fluorinated, and hybrid hydrogenated-fluorinated JDs are reported to coassemble by film hydration at specific ratios into an unprecedented class of supramolecular Janus particles (JPs) denoted Janus dendrimersomes (JDSs). They consist of a dumbbell-shaped structure composed of an onion-like hydrogenated vesicle and an onion-like fluorinated vesicle tethered together. The synthesis of dye-tagged analogs of each JD component enabled characterization of JDS architectures with confocal fluorescence microscopy. Additionally, a simple injection method was used to prepare submicron JDSs, which were imaged with cryogenic transmission electron microscopy (cryo-TEM). As reported previously, different ratios of the same three-component system yielded a variety of structures including homogenous onion-like vesicles, core-shell structures, and completely self-sorted hydrogenated and fluorinated vesicles. Taken together with the JDSs reported herein, a self-sorting pathway is revealed as a function of the relative concentration of the hybrid JD, which may serve to stabilize the interface between hydrogenated and fluorinated bilayers. The fission-like pathway suggests the possibility of fusion and fission processes in biological systems that do not require the assistance of proteins but instead may result from alterations in the ratios of membrane composition.
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