Evidence map›Paper›PMID 28784724›Full record

ArticleMolecular and cellular biology2017

Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase.

Michael C Reubens, Sophie Rozenzhak, Paul Russell

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael C ReubensDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.
Sophie RozenzhakDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.
Paul RussellDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA prussell@scripps.edu.ORCID http://orcid.org/0000-0001-8575-1046
Scripps Research Institute · US

Funding

Studies of the DNA damage checkpointsR01CA077325 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI RUSSELL, PAUL · 1998 to 2017
$7.1M
Studies of the DNA Replication CheckpointR01GM059447 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI RUSSELL, PAUL · 1999 to 2016
$6.0M
Mre11/Rad50 Structural Biology for DNA Damage ResponsesR01CA117638 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI RUSSELL, PAUL, TAINER, JOHN A. · 2005 to 2019
$5.6M
NCI NIH HHS R01 CA077325NCI NIH HHS R01 CA117638NIGMS NIH HHS R01 GM059447
6 · The paper itself

Abstract

DNA replication involves the inherent risk of genome instability, since replisomes invariably encounter DNA lesions or other structures that stall or collapse replication forks during the S phase. In the fission yeast

Indexed as

Genomic InstabilityCell Cycle ProteinsDNA ReplicationGenome, FungalHistonesMutationPhosphorylationProtein BindingProtein DomainsSchizosaccharomycesSchizosaccharomyces pombe ProteinsS PhaseUbiquitin-Protein LigasesBrc1 protein, S pombeCell Cycle ProteinsHistonesRhp18 protein, S pombeSchizosaccharomyces pombe Proteinssmc6 protein, S pombeUbiquitin-Protein LigasesBrc1BRCT domainDNA damageDNA repairDNA replication stressgenome integrityRad18Rhp18

Identifiers

PMID28784724
PMCPMC5660468
OpenAlexW2950392557

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.