Evidence map›Paper›PMID 28784722›Full record

ArticleMolecular and cellular biology2017

Cleavage Alters the Molecular Determinants of Protein Kinase C-δ Catalytic Activity.

Jianli Gong, Misun Park, Susan F Steinberg

Abstract read
In one paragraph

Article in Molecular and cellular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jianli GongDepartment of Pharmacology, Columbia University, New York, New York, USA.
Misun ParkDepartment of Pharmacology, Columbia University, New York, New York, USA.
Susan F SteinbergDepartment of Pharmacology, Columbia University, New York, New York, USA sfs1@columbia.edu.

Funding

Distinct Protein Kinase C-Delta Signaling Modes in CardiomyocytesR01HL123061 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEINBERG, SUSAN F · 2015 to 2018
$2.2M
NHLBI NIH HHS R01 HL123061
6 · The paper itself

Abstract

Protein kinase C-δ (PKCδ) is an allosterically activated enzyme that acts much like other PKC isoforms to transduce growth factor-dependent signaling responses. However, PKCδ is unique in that activation loop (Thr

Indexed as

apoptosisprotein kinase Cprotein phosphorylationSrc

Identifiers

PMID28784722
PMCPMC5615191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.