Evidence map›Paper›PMID 28784719›Full record

ArticleMolecular and cellular biology2017

Drosophila Dosage Compensation Loci Associate with a Boundary-Forming Insulator Complex.

Emily G Kaye, Amina Kurbidaeva, Daniel Wolle, Tsutomu Aoki, Paul Schedl, Erica Larschan

Abstract read
In one paragraph

Article in Molecular and cellular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
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  4. Zelda is dispensable forMolecular biology of the cell · 2025
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  8. Set2 and H3K36 regulate thebioRxiv : the preprint server for biology · 2024
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  9. Sequence reliance of abioRxiv : the preprint server for biology · 2023
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  10. Mechanisms of Interaction between Enhancers and Promoters in ThreeInternational journal of molecular sciences · 2023
    Review
  11. Dimerization Activity of a Disordered N-Terminal Domain fromInternational journal of molecular sciences · 2022
    Article
  12. Review
  13. Article
  14. Review
  15. GAGA factor: a multifunctional pioneering chromatin protein.Cellular and molecular life sciences : CMLS · 2021
    Review
  16. Article
  17. Article
  18. The insulator functions of theScience advances · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emily G KayeDepartment of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, Rhode Island, USA.
Amina KurbidaevaDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Daniel WolleDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Tsutomu AokiDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Paul SchedlDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Erica LarschanDepartment of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, Rhode Island, USA Erica_Larschan@brown.edu.

Funding

MOLECULAR AND GENETIC ANALYSIS OF CHROMATIN STRUCTURER01GM043432 · NIGMS · PRINCETON UNIVERSITY · PI SCHEDL, PAUL D · 1990 to 2017
$5.8M
Predoctoral Training in the Molecular Biology of AgingT32AG041688 · NIA · BROWN UNIVERSITY · PI NICOLA NERETTI, John M Sedivy · 2012 to 2026
$3.5M
Establishing coordinate gene regulation during Drosophila dosage compensationR01GM098461 · NIGMS · BROWN UNIVERSITY · PI LARSCHAN, ERICA NICOLE · 2011 to 2016
$2.1M
Molecular and Genetic Analysis of Chromatin StructureR56GM043432 · NIGMS · PRINCETON UNIVERSITY · PI SCHEDL, PAUL D · 2008 to 2008
$389k
NIA NIH HHS T32 AG041688NIGMS NIH HHS R01 GM043432NIGMS NIH HHS R01 GM098461NIGMS NIH HHS R56 GM043432
6 · The paper itself

Abstract

Chromatin entry sites (CES) are 100- to 1,500-bp elements that recruit male-specific lethal (MSL) complexes to the X chromosome to upregulate expression of X-linked genes in male flies. CES contain one or more ∼20-bp GA-rich sequences called MSL recognition elements (MREs) that are critical for dosage compensation. Recent studies indicate that CES also correspond to boundaries of X-chromosomal topologically associated domains (TADs). Here, we show that an ∼1,000-kDa complex called the late boundary complex (LBC), which is required for the functioning of the Bithorax complex boundary

Indexed as

AnimalsDosage Compensation, GeneticDrosophila melanogasterDrosophila ProteinsGenes, X-LinkedGenetic LociInsulator ElementsMaleMutationX ChromosomeDrosophila Proteinsboundarieschromatin entry sitesCLAMPdosage compensationDrosophilaGAGA factorinsulatorsmale-specific lethal complexesMSL recognition elementsTADs

Identifiers

PMID28784719
PMCPMC5640815

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.