Evidence map›Paper›PMID 28784718›Full record

ArticleMolecular and cellular biology2017

TRMT1-Catalyzed tRNA Modifications Are Required for Redox Homeostasis To Ensure Proper Cellular Proliferation and Oxidative Stress Survival.

Joshua M Dewe, Benjamin L Fuller, Jenna M Lentini, Stefanie M Kellner, Dragony Fu

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 122 citations in OpenAlex.

  1. Article
  2. Thermophysical Properties of a tRNA Isodecoder.The journal of physical chemistry. B · 2026
    Article
  3. Article
  4. TRMT1-mediated tRNA mCell death & disease · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. TRMT1L-catalyzed mCell reports · 2025
    Article
  19. Article
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Joshua M DeweDepartment of Biology, Center for RNA Biology, University of Rochester, Rochester, New York, USA.
Benjamin L FullerDepartment of Biology, Center for RNA Biology, University of Rochester, Rochester, New York, USA.
Jenna M LentiniDepartment of Biology, Center for RNA Biology, University of Rochester, Rochester, New York, USA.
Stefanie M KellnerLMU Munich, Department of Chemistry, Munich, Germany.ORCID http://orcid.org/0000-0003-3224-7502
Dragony FuDepartment of Biology, Center for RNA Biology, University of Rochester, Rochester, New York, USA dragonyfu@rochester.edu.ORCID http://orcid.org/0000-0002-8725-8658
University of Rochester · USLMU Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the tRNA methyltransferase 1 (

Indexed as

CatalysisCell ProliferationCell SurvivalGuanosineHEK293 CellsHeLa CellsHomeostasisHumansIntellectual DisabilityMutationOxidation-ReductionOxidative StressReactive Oxygen SpeciesRNA, TransfertRNA Methyltransferases8-methylguanosineGuanosineReactive Oxygen SpeciesRNA, TransferTRMT1 protein, humantRNA Methyltransferasesdimethylguanosineintellectual disabilitymethylationmethyltransferasemodificationneurodevelopmentRNATrm1TRMT1tRNA modification

Identifiers

PMID28784718
PMCPMC5640816
OpenAlexW2742420066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.