Trial reportPediatrics2017
Early Probiotic Supplementation for Eczema and Asthma Prevention: A Randomized Controlled Trial.
Trial report in Pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04662619 (A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled, Two-Arm, Parallel-Group, Nutritional Intervention Study to Examine the Clinical and Immunological Effects of a Probiotic Food Supplement Containing B. Infantis), which is not on this map. Cited by 85 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled, Two-Arm, Parallel-Group, Nutritional Intervention Study to Examine the Clinical and Immunological Effects of a Probiotic Food Supplement Containing B. Infantis (EVC001) in Healthy Breastfed Infants at Risk of Developing Atopic Dermatitis
Who cites it
85 citing papers in PubMed, 11 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Effects of probiotics, prebiotics, and synbiotics on lung function and symptoms in adults with bronchial asthma: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- The association between early-life respiratory infections and childhood asthma: a meta-analytic perspective.Frontiers in medicine · 2026Pooled it
- Probiotics in infants for prevention of allergic disease.The Cochrane database of systematic reviews · 2025Pooled it
- Association of Probiotics with Atopic Dermatitis among Infant: A Meta-analysis of Randomized Controlled Trials.Oxidative medicine and cellular longevity · 2022Pooled it
- Postnatal probiotic supplementation can prevent and optimize treatment of childhood asthma and atopic disorders: A systematic review of randomized controlled trials.Frontiers in pediatrics · 2022Pooled it
- Can Mixed Strains ofNutrients · 2021Pooled it
- Efficacy of Single-Strain Probiotics Versus Multi-Strain Mixtures: Systematic Review of Strain and Disease Specificity.Digestive diseases and sciences · 2021Pooled it
- Pooled it
- Probiotic Supplementation During the Perinatal and Infant Period: Effects on Gut Dysbiosis and Disease.Nutrients · 2020Pooled it
- [Effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Pooled it
- Pooled it
- A randomized, double-blind, placebo-controlled trial of soluble corn fiber supplementation for children with asthma.Frontiers in allergy · 2025Trial
- Maternal and infant probiotic administration for morbidity of very low birth weight infants: a three-arm randomized placebo-controlled trial.European journal of nutrition · 2022Trial
- Pilot Analysis of Early Lactobacillus rhamnosus GG for Infant Colic Prevention.Journal of pediatric gastroenterology and nutrition · 2019Trial
- Delayed gut microbiota development in high-risk for asthma infants is temporarily modifiable by Lactobacillus supplementation.Nature communications · 2018Trial
- The Gut-Skin Axis in Pediatric Atopic Dermatitis: Nutritional Modulation, Microbiome Interactions, and Emerging Precision Approaches.Nutrients · 2026Review
- Probiotics in asthma: immunoregulatory mechanisms and emerging opportunities for respiratory delivery-a narrative review.Translational pediatrics · 2026Review
- [Gut microbiota and allergic diseases].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Review
- Microbiota-directed therapies for atopic dermatitis: a three-tier framework for inflammation control, immune modulation, and microbiome restoration.Frontiers in immunology · 2026Review
- From Womb to World: Unravelling the Microbiota's Impact on Health and Disease.International journal of microbiology · 2026Review
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
objectivesTo determine if probiotic administration during the first 6 months of life decreases childhood asthma and eczema.
methodsWe conducted a randomized, double-blind controlled trial of
resultsInfants were accrued over a 6-year period (median follow-up: 4.6 years; 95% retention rate at 2 years). At 2 years of age, the estimated cumulative incidence of eczema was 30.9% (95% confidence interval [CI], 21.4%-40.4%) in the control arm and 28.7% (95% CI, 19.4%-38.0%) in the LGG arm, for a hazard ratio of 0.95 (95% CI, 0.59-1.53) (log-rank
conclusionsFor high-risk infants, early LGG supplementation for the first 6 months of life does not appear to prevent the development of eczema or asthma at 2 years of age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.