Evidence map›Paper›PMID 28784688›Full record

ArticleCirculation. Heart failure2017

Relaxation and the Role of Calcium in Isolated Contracting Myocardium From Patients With Hypertensive Heart Disease and Heart Failure With Preserved Ejection Fraction.

K Elisabeth Runte, Stephen P Bell, Donald E Selby, Tim N Häußler, Takamuru Ashikaga, Martin M LeWinter, Bradley M Palmer, Markus Meyer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

K Elisabeth RunteFrom the Division of Cardiology, Department of Medicine (K.E.R., S.P.B., D.E.S., T.N.H., M.M.L., M.M.), Biostatistics Unit (T.A.), and Department of Molecular Physiology and Biophysics (M.M.L., B.M.P.), Larner College of Medicine at the University of Vermont, Burlington.
Stephen P BellFrom the Division of Cardiology, Department of Medicine (K.E.R., S.P.B., D.E.S., T.N.H., M.M.L., M.M.), Biostatistics Unit (T.A.), and Department of Molecular Physiology and Biophysics (M.M.L., B.M.P.), Larner College of Medicine at the University of Vermont, Burlington.
Donald E SelbyFrom the Division of Cardiology, Department of Medicine (K.E.R., S.P.B., D.E.S., T.N.H., M.M.L., M.M.), Biostatistics Unit (T.A.), and Department of Molecular Physiology and Biophysics (M.M.L., B.M.P.), Larner College of Medicine at the University of Vermont, Burlington.
Tim N HäußlerFrom the Division of Cardiology, Department of Medicine (K.E.R., S.P.B., D.E.S., T.N.H., M.M.L., M.M.), Biostatistics Unit (T.A.), and Department of Molecular Physiology and Biophysics (M.M.L., B.M.P.), Larner College of Medicine at the University of Vermont, Burlington.
Takamuru AshikagaFrom the Division of Cardiology, Department of Medicine (K.E.R., S.P.B., D.E.S., T.N.H., M.M.L., M.M.), Biostatistics Unit (T.A.), and Department of Molecular Physiology and Biophysics (M.M.L., B.M.P.), Larner College of Medicine at the University of Vermont, Burlington.
Martin M LeWinterFrom the Division of Cardiology, Department of Medicine (K.E.R., S.P.B., D.E.S., T.N.H., M.M.L., M.M.), Biostatistics Unit (T.A.), and Department of Molecular Physiology and Biophysics (M.M.L., B.M.P.), Larner College of Medicine at the University of Vermont, Burlington.
Bradley M PalmerFrom the Division of Cardiology, Department of Medicine (K.E.R., S.P.B., D.E.S., T.N.H., M.M.L., M.M.), Biostatistics Unit (T.A.), and Department of Molecular Physiology and Biophysics (M.M.L., B.M.P.), Larner College of Medicine at the University of Vermont, Burlington.
Markus MeyerFrom the Division of Cardiology, Department of Medicine (K.E.R., S.P.B., D.E.S., T.N.H., M.M.L., M.M.), Biostatistics Unit (T.A.), and Department of Molecular Physiology and Biophysics (M.M.L., B.M.P.), Larner College of Medicine at the University of Vermont, Burlington. markus.meyer@uvmhealth.org.
University of Vermont · US

Funding

Vermont INBRE Administrative Supplement 2024 AWD 118P20GM103449 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI CHRISTOPHER S FRANCKLYN · 2012 to 2026
$58.4M
Myofilament-based mechanisms of diastolic dysfunction in HFpEFR01HL118524 · NHLBI · UNIVERSITY OF ARIZONA · PI GRANZIER, HENK L., LEWINTER, MARTIN M · 2014 to 2017
$2.5M
Sarcolemmal Calcium Extrusion Defect in Patients with Diastolic DysfunctionR01HL122744 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI LUSTGARTEN, DANIEL L, MEYER, MARKUS · 2015 to 2019
$1.9M
NHLBI NIH HHS R01 HL118524NHLBI NIH HHS R01 HL122744NIGMS NIH HHS P20 GM103449
6 · The paper itself

Abstract

backgroundRelaxation characteristics and Ca METHODS AND

resultsRelaxation characteristics were studied in myocardial strip preparations under physiological conditions at stimulation rates of 60 and 180 per minute. Intracellular Ca

conclusionsContraction and relaxation are prolonged in isolated myocardium from patients with HHD and HHD+HFpEF. This leads to incomplete relaxation at higher rates. Elevated calcium levels in HFpEF are neither a result of an impaired Na

Indexed as

AgedBiopsyBlotting, WesternCalciumDiastoleFemaleHeart FailureHeart VentriclesHumansHypertensionMaleMiddle AgedMyocardial ContractionMyocardiumStroke VolumeVentricular Function, LeftCalciumdiastoleFura-2heart failuresodium

Identifiers

PMID28784688
PMCPMC5567852
OpenAlexW2743895735

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.