Evidence map›Paper›PMID 28784680›Full record

ArticleAntimicrobial agents and chemotherapy2017

N-Acylated Derivatives of Sulfamethoxazole Block Chlamydia Fatty Acid Synthesis and Interact with FabF.

Sergio A Mojica, Olli Salin, Robert J Bastidas, Naresh Sunduru, Mattias Hedenström, C David Andersson, Carlos Núñez-Otero, Patrik Engström, Raphael H Valdivia, Mikael Elofsson and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. A 2-pyridone amide inhibitor of transcriptional activity inAntimicrobial agents and chemotherapy · 2023
    Article
  3. Article
  4. Article
  5. Synthesis, Spectroscopic Characterization, andMolecules (Basel, Switzerland) · 2018
    Article
  6. Evaluating the Antibiotic Susceptibility ofFrontiers in microbiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Sergio A MojicaDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.
Olli SalinDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.
Robert J BastidasDepartment of Molecular Genetics and Microbiology and Center for the Genomics of Microbial Systems, Duke University Medical Center, Durham, North Carolina, USA.
Naresh SunduruDepartment of Chemistry, Umeå University, Umeå, Sweden.
Mattias HedenströmDepartment of Chemistry, Umeå University, Umeå, Sweden.
C David AnderssonDepartment of Chemistry, Umeå University, Umeå, Sweden.
Carlos Núñez-OteroDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.
Patrik EngströmDepartment of Molecular Biology, Umeå University, Umeå, Sweden.
Raphael H ValdiviaDepartment of Molecular Genetics and Microbiology and Center for the Genomics of Microbial Systems, Duke University Medical Center, Durham, North Carolina, USA.
Mikael ElofssonDepartment of Chemistry, Umeå University, Umeå, Sweden.
Åsa GylfeDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden asa.gylfe@umu.se.
Umeå University · SEDuke Medical Center · USDuke University Hospital · US

Funding

Forward and Reverse Genetics in ChlamydiaR01AI100759 · NIAID · DUKE UNIVERSITY · PI VALDIVIA, RAPHAEL H · 2012 to 2016
$2.2M
Data commons for 'omic, microscopy and analysis core facilitiesS10OD018164 · OD · DUKE UNIVERSITY · PI WRAY, GREGORY A. · 2014 to 2014
$598k
NIAID NIH HHS R01 AI100759NIH HHS S10 OD018164
6 · The paper itself

Abstract

The type II fatty acid synthesis (FASII) pathway is essential for bacterial lipid biosynthesis and continues to be a promising target for novel antibacterial compounds. Recently, it has been demonstrated that

Indexed as

AcylationAdamantaneAminobenzoatesAnilidesAnimalsAnti-Bacterial AgentsCell Line, TumorCeruleninChlamydia InfectionsChlamydia trachomatisChlorocebus aethiopsFatty AcidsFatty Acid Synthase, Type IIFatty Acid Synthesis InhibitorsHeLa CellsHumansAdamantaneAminobenzoatesAnilidesAnti-Bacterial AgentsCeruleninFatty AcidsFatty Acid Synthase, Type IIFatty Acid Synthesis InhibitorsplatensimycinSulfamethoxazoleTriclosanantimicrobial agentsChlamydia trachomatisdrug targetsFAS

Identifiers

PMID28784680
PMCPMC5610512
OpenAlexW2744430390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.