Evidence map›Paper›PMID 28784679›Full record

ArticleAntimicrobial agents and chemotherapy2017

The Fluorocycline TP-271 Is Efficacious in Models of Aerosolized Bacillus anthracis Infection in BALB/c Mice and Cynomolgus Macaques.

Trudy H Grossman, Michael S Anderson, Lindsay Drabek, Melanie Gooldy, Henry S Heine, Lisa N Henning, Winston Lin, Joseph V Newman, Rene Nevarez, Kaylyn Siefkas-Patterson and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Postexposure Prophylaxis and Treatment of Bacillus anthracis Infections: A Systematic Review and Meta-analyses of Animal Models, 1947-2019.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Trudy H GrossmanTetraphase Pharmaceuticals, Inc., Watertown, Massachusetts, USA tgrossman@yahoo.com.
Michael S AndersonBattelle, Columbus, Ohio, USA.
Lindsay DrabekIIT Research Institute, Chicago, Illinois, USA.
Melanie GooldyCUBRC, Inc., Buffalo, New York, USA.
Henry S HeineUnited States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Lisa N HenningBattelle, Columbus, Ohio, USA.
Winston LinIIT Research Institute, Chicago, Illinois, USA.
Joseph V NewmanTetraphase Pharmaceuticals, Inc., Watertown, Massachusetts, USA.
Rene NevarezIIT Research Institute, Chicago, Illinois, USA.
Kaylyn Siefkas-PattersonIIT Research Institute, Chicago, Illinois, USA.
Anne K RadcliffCUBRC, Inc., Buffalo, New York, USA.
Joyce A SutcliffeTetraphase Pharmaceuticals, Inc., Watertown, Massachusetts, USA.
IIT Research Institute · USTetraphase Pharmaceuticals (United States) · USBattelle · USCalspan-University of Buffalo Research Center · USUnited States Army Medical Research Institute of Infectious Diseases · US

Funding

Development of TP-217 as a highly efficacious, broad-spectrum antibiotic for theR01AI093484 · NIAID · CUBRC, INC. · PI GROSSMAN, TRUDY HOPE, RADCLIFF, ANNE KATHLEEN · 2011 to 2015
$2.8M
NIAID NIH HHS HHSN272201100028CNIAID NIH HHS R01 AI093484
6 · The paper itself

Abstract

The fluorocycline TP-271 was evaluated in mouse and nonhuman primate (NHP) models of inhalational anthrax. BALB/c mice were exposed by nose-only aerosol to

Indexed as

AnimalsAnthraxAnti-Bacterial AgentsAntibodies, BacterialAntibodies, NeutralizingAntigens, BacterialBacillus anthracisBacterial ToxinsDisease Models, AnimalFemaleImmunoglobulin GMacaca fascicularisMiceMice, Inbred BALB CMicrobial Sensitivity TestsPost-Exposure Prophylaxisanthrax toxinAnti-Bacterial AgentsAntibodies, BacterialAntibodies, NeutralizingAntigens, BacterialBacterial ToxinsImmunoglobulin GTetracyclinesTP-271anthraxBacillus anthracisfluorocyclineTP-271

Identifiers

PMID28784679
PMCPMC5610513
OpenAlexW2744996835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.