ArticleJournal of the American Heart Association2017
Physical Activity, Sedentary Behavior, and Long-Term Changes in Aortic Stiffness: The Whitehall II Study.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Health Benefits of Different Sports: a Systematic Review and Meta-Analysis of Longitudinal and Intervention Studies Including 2.6 Million Adult Participants.Sports medicine - open · 2024Pooled it
- Pooled it
- Intradialytic Exercise: Effects on Arterial Stiffness and Gait Speed in Patients Undergoing Hemodialysis.Medical science monitor : international medical journal of experimental and clinical research · 2025Trial
- Functional Limitations and Exercise Intolerance in Patients With Post-COVID Condition: A Randomized Crossover Clinical Trial.JAMA network open · 2024Trial
- Trial
- Screen Time and Chronic Pain Health: Mendelian Randomization Study.Journal of medical Internet research · 2026Article
- Association of Vascular Age and Subclinical Target Organ Damage in a Beijing Community-Based Population: A Cross-Sectional Study.Journal of cardiovascular development and disease · 2026Article
- Central blood pressure and arterial stiffness among ultramarathon runners across the lifespan.European journal of applied physiology · 2026Article
- Association between cardiorespiratory fitness and impaired vascular function in type 2 diabetes.World journal of diabetes · 2025Article
- Sit-Stand Transitions in Postmenopausal Women: Big Implications for a Small Change.Circulation · 2025Article
- Association of physical activity, sedentary time, and sleep with maternal vascular function in women with a history of preeclampsia.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Characterizing biomarkers of ageing in Singaporeans: the ABIOS observational study protocol.GeroScience · 2025Article
- Eight months of marathon school training reduced blood pressure, systemic vascular resistance and extracellular water volume.Scientific reports · 2025Article
- Associations of physical activity and sedentary time with aortic stiffness and autonomic function in early pregnancy.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Physical activity and cardiovascular risk in obese older Korean women: effects on obesity, hypertension, and arterial stiffness.Frontiers in public health · 2025Article
- Arterial aging and the autonomic nervous system: is the relationship differently modified by physical activity in men and women?Frontiers in aging · 2025Article
- Central Pulse Wave Velocity and Augmentation Index Are Repeatable and Reproducible Measures of Arterial Function.Health science reports · 2024Article
- The Relationship between Healthy Vascular Aging with the Mediterranean Diet and Other Lifestyles in the Spanish Population: The EVA Study.Nutrients · 2024Article
- Associations of movement behaviours and dietary intake with arterial stiffness: results from the ORISCAV-LUX 2 cross-sectional study.BMJ open · 2024Article
- Determinants of hand pulse wave velocity and hand pulse transit time in healthy adults.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundPhysical activity is associated with reduced cardiovascular disease risk, mainly through effects on atherosclerosis. Aortic stiffness may be an alternative mechanism. We examined whether patterns of physical activity and sedentary behavior are associated with rate of aortic stiffening. METHODS AND
resultsCarotid-femoral pulse wave velocity (PWV) was measured twice using applanation tonometry at mean ages 65 (in 2008/2009) and 70 (in 2012/2013) years in the Whitehall-II study (N=5196). Physical activity was self-reported at PWV baseline (2008/2009) and twice before (in 1997/1999 and 2002/2003). Sedentary time was defined as sitting time watching television or at work/commute. Linear mixed models adjusted for metabolic and lifestyle risk factors were used to analyze PWV change. Mean (SD) PWV (m/s) was 8.4 (2.4) at baseline and 9.2 (2.7) at follow-up, representing a 5-year increase of 0.76 m/s (95% CI 0.69, 0.83). A smaller 5-year increase in PWV was observed for each additional hour/week spent in sports activity (-0.02 m/s [95% CI -0.03, -0.001]) or cycling (-0.02 m/s [-0.03, -0.008]). Walking, housework, gardening, or do-it-yourself activities were not significantly associated with aortic stiffening. Each additional hour/week spent sitting was associated with faster PWV progression in models adjusted for physical activity (0.007 m/s [95% CI 0.001, 0.013]). Increasing physical activity over time was associated with a smaller subsequent increase in PWV (-0.16 m/s [-0.32, -0.002]) compared with not changing activity levels.
conclusionsHigher levels of moderate-to-vigorous physical activity and avoidance of sedentary behavior were each associated with a slower age-related progression of aortic stiffness independent of conventional vascular risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.