ArticleEndocrine connections2017
Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management.
Article in Endocrine connections, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Well-differentiated G1 and G2 pancreatic neuroendocrine tumors: a meta-analysis of published expanded DNA sequencing data.Frontiers in endocrinology · 2024Pooled it
- Article
- Insulinoma-Accurate Preoperative Localization Is the Key to Management: An Initial Experience.Indian journal of surgical oncology · 2022Article
- The functioning side of the pancreas: a review on insulinomas.Journal of endocrinological investigation · 2020Review
- Asymptomatic Hyperinsulinaemic Hypoglycaemia.European journal of case reports in internal medicine · 2020Article
- Analysis of blood glucose distribution characteristics in a health examination population in Chengdu (2007-2015).Medicine · 2017Article
- The incidence of insulinoma in Western Sweden between 2002 and 2019.Annals of gastroenterologyArticle
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveIn adults with hyperinsulinaemic hypoglycaemia (HH), in particular those with insulinoma, the optimal diagnostic and management strategies remain uncertain. Here, we sought to characterise the biochemical and radiological assessment, and clinical management of adults with HH at a tertiary centre over a thirteen-year period.
designClinical, biochemical, radiological and histological data were reviewed from all confirmed cases of adult-onset hyperinsulinaemic hypoglycaemia at our centre between 2003 and 2016. In a subset of patients with stage I insulinoma, whole-exome sequencing of tumour DNA was performed.
resultsTwenty-nine patients were identified (27 insulinoma, including 6 subjects with metastatic disease; 1 pro-insulin/GLP-1 co-secreting tumour; 1 activating glucokinase mutation). In all cases, hypoglycaemia (glucose ≤2.2 mmol/L) was achieved within 48 h of a supervised fast. At fast termination, subjects with stage IV insulinoma had significantly higher insulin, C-peptide and pro-insulin compared to those with insulinoma staged I-IIIB. Preoperative localisation of insulinoma was most successfully achieved with EUS. In two patients with inoperable, metastatic insulinoma, peptide receptor radionuclide therapy (PRRT) with
conclusionOur study highlights, in particular, the utility of the 48-h fast in the diagnosis of insulinoma, EUS for tumour localisation and the value of PRRT therapy in the treatment of metastatic disease.
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Registered trials
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