Evidence map›Paper›PMID 28784560›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2017

Adipose Stem Cell Therapy Mitigates Chronic Pancreatitis via Differentiation into Acinar-like Cells in Mice.

Zhen Sun, Wenyu Gou, Do-Sung Kim, Xiao Dong, Charlie Strange, Yu Tan, David B Adams, Hongjun Wang

Open access · greenAbstract read
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. AAT-MSC-EVs: Novel implications for suppressing ferroptosis, fibrosis and pain associated with chronic pancreatitis.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  2. Review
  3. Review
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  7. Article
  8. Review
  9. Review
  10. Article
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  12. Article
  13. In search of elixir: Pharmacological agents against stem cell senescence.Iranian journal of basic medical sciences · 2021
    Review
  14. A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion.Journal of visualized experiments : JoVE · 2021
    Article
  15. Article
  16. Article
  17. Stem cell therapy: a potential for the perils of pancreatitis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020
    Review
  18. Article
  19. Adipose Stem Cell Therapy for Chronic Pancreatitis.Molecular therapy : the journal of the American Society of Gene Therapy · 2017
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Zhen SunDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA; Qingdao Agricultural University, Qingdao, Shandong 266109, China.
Wenyu GouDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
Do-Sung KimDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
Xiao DongQingdao Agricultural University, Qingdao, Shandong 266109, China.
Charlie StrangeDepartment of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Yu TanBioengineering Department, Clemson University, Clemson, SC 29634, USA.
David B AdamsDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
Hongjun WangDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: wangho@musc.edu.
Medical University of South Carolina · USQingdao Agricultural University · CNClemson University · US

Funding

Alpha1 Anti-trypsin Enhances Islet Autograft SurvivalR01DK105183 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI WANG, HONGJUN · 2016 to 2020
$2.0M
A Novel Approach to Prevent Surgical Diabetes in Chronic Pancreatitis PatientsR21DK097544 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI WANG, HONGJUN · 2014 to 2015
$411k
Islet and Mesenchymal Stem Cell Co-transplantation Prevents Onset of DiabetesR21DK099696 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI WANG, HONGJUN · 2013 to 2014
$411k
Novel Strategies to Increase Insulin Independence after Islet AutotransplantationR03EB015744 · NIBIB · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI WANG, HONGJUN · 2013 to 2014
$147k
NIBIB NIH HHS R03 EB015744NIDDK NIH HHS R01 DK105183NIDDK NIH HHS R21 DK097544NIDDK NIH HHS R21 DK099696
6 · The paper itself

Abstract

The objective of this study was to assess the capacity of adipose-derived mesenchymal stem cells (ASCs) to mitigate disease progression in an experimental chronic pancreatitis mouse model. Chronic pancreatitis (CP) was induced in C57BL/6 mice by repeated ethanol and cerulein injection, and mice were then infused with 4 × 10

Indexed as

Mesenchymal Stem Cell TransplantationAcinar CellsAdipose TissueAmylasesAnimalsCell- and Tissue-Based TherapyCell DifferentiationCell MovementCeruletideCoculture TechniquesCulture Media, ConditionedEthanolGene ExpressionGenes, ReporterGreen Fluorescent ProteinsHumansAmylasesCeruletideCulture Media, ConditionedEthanolGreen Fluorescent ProteinsInterleukin-6Interleukin-6 Inhibitorsinterleukin-6, mouseTumor Necrosis Factor-alphaacinar cellsadipose stem cell therapydifferentiationethanol and cerulean-induced chronic pancreatitis mouse modelfibrosisinflammationmesenchymal stem cells

Identifiers

PMID28784560
PMCPMC5675167
OpenAlexW2632665022

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.