ReviewTranslational research : the journal of laboratory and clinical medicine2017
Large-scale 3-dimensional quantitative imaging of tissues: state-of-the-art and translational implications.
Review in Translational research : the journal of laboratory and clinical medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Distributed and networked analysis of volumetric image data for remote collaboration of microscopy image analysis.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Precision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Article
- Integrated Cytometry With Machine Learning Applied to High-Content Imaging of Human Kidney Tissue for In Situ Cell Classification and Neighborhood Analysis.Laboratory investigation; a journal of technical methods and pathology · 2023Article
- Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns.PLoS pathogens · 2022Article
- Cellular and molecular interrogation of kidney biopsy specimens.Current opinion in nephrology and hypertension · 2022Review
- Tissue Cytometry With Machine Learning in Kidney: From Small Specimens to Big Data.Frontiers in physiology · 2022Review
- VEGFR3 tyrosine kinase inhibition aggravates cisplatin nephrotoxicity.American journal of physiology. Renal physiology · 2021Article
- Quantitative 3-dimensional imaging and tissue cytometry reveals lymphatic expansion in acute kidney injury.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- In Situ Classification of Cell Types in Human Kidney Tissue Using 3D Nuclear Staining.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2021Article
- Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- The Indiana O'Brien Center for Advanced Renal Microscopic Analysis.American journal of physiology. Renal physiology · 2021Review
- Digital Image Analysis Tools Developed by the Indiana O'Brien Center.Frontiers in physiology · 2021Review
- Kidney Histopathology and Prediction of Kidney Failure: A Retrospective Cohort Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2020Article
- A Precision Medicine Approach Uncovers a Unique Signature of Neutrophils in Patients With Brushite Kidney Stones.Kidney international reports · 2020Article
- Fluorescence microscopy tensor imaging representations for large-scale dataset analysis.Scientific reports · 2020Article
- DeepSynth: Three-dimensional nuclear segmentation of biological images using neural networks trained with synthetic data.Scientific reports · 2019Article
- Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.Journal of the American Society of Nephrology : JASN · 2018Article
- Quantitative Large-Scale Three-Dimensional Imaging of Human Kidney Biopsies: A Bridge to Precision Medicine in Kidney Disease.Nephron · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Recent developments in automated optical sectioning microscope systems have enabled researchers to conduct high resolution, three-dimensional (3D) microscopy at the scale of millimeters in various types of tissues. This powerful technology allows the exploration of tissues at an unprecedented level of detail, while preserving the spatial context. By doing so, such technology will also enable researchers to explore cellular and molecular signatures within tissue and correlate with disease course. This will allow an improved understanding of pathophysiology and facilitate a precision medicine approach to assess the response to treatment. The ability to perform large-scale imaging in 3D cannot be realized without the widespread availability of accessible quantitative analysis. In this review, we will outline recent advances in large-scale 3D imaging and discuss the available methodologies to perform meaningful analysis and potential applications in translational research.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.