ReviewParkinsonism & related disorders2018
Evolving concepts in the pathogenesis of dystonia.
Review in Parkinsonism & related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- Inhibitory Circuits of the Sensorimotor Network are Not Modulated By Cerebellar Transcranial Direct Current Stimulation in Isolated Cervical Dystonia.Cerebellum (London, England) · 2026Trial
- Deutetrabenazine in Hyperkinetic Movement Disorders: VMAT2 Modulation From Choreiform Disorders to Hyperkinetic Dystonic Syndromes.Journal of central nervous system disease · 2026Review
- Dystonia Secondary to Intramedullary Lesion of Spinal Cord: A Case Report.Annals of Indian Academy of Neurology · 2026Article
- Anti-dipeptidyl-peptidase-like protein-6 (DPPX) autoimmune encephalitis associated with severe multifocal dystonia.Clinical parkinsonism & related disorders · 2025Article
- Mutation in Prkra results in cerebellar abnormality and reduced eIF2α phosphorylation in a model of DYT-PRKRA.Disease models & mechanisms · 2024Article
- Whole-exome sequencing in a cohort of Chinese patients with isolated cervical dystonia.Heliyon · 2024Article
- A frameshift mutation in the murinebioRxiv : the preprint server for biology · 2024Article
- Genetic Update and Treatment for Dystonia.International journal of molecular sciences · 2024Review
- Review
- Decoding Dystonia in Autoimmune Disorders: A Scoping Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Cerebellar Dysfunction as a Source of Dystonic Phenotypes in Mice.Cerebellum (London, England) · 2023Article
- Pathophysiology of Dyt1-Science translational medicine · 2023Article
- Dystonia Responding to Levodopa in A Child with Myoclonus-Dystonia.Movement disorders clinical practice · 2023Article
- Impaired trunk control and its relationship with balance, functional mobility, and disease severity in patients with cervical dystonia.Turkish journal of medical sciences · 2023Article
- Cerebellar dysfunction in rodent models with dystonia, tremor, and ataxia.Dystonia (Lausanne, Switzerland) · 2023Article
- A novel compound heterozygous mutation ofFrontiers in neurology · 2023Article
- Electromyography as a Method for Distinguishing Dystonia in Mice.Advances in neurobiology · 2023Article
- Diphenhydramine induced acute dystonia: a case report.The Pan African medical journal · 2022Article
- A cross-sectional study of walking, balance and upper limb assessment scales in people with cervical dystonia.Journal of neural transmission (Vienna, Austria : 1996) · 2021Observational
- Haloperidol-induced isolated lingual dystonia.BMJ case reports · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
introductionThe dystonias are a group of disorders defined by over-contraction of muscles leading to abnormal movements and postures. In recent years, enormous advances have been made in elucidating the neurobiological mechanisms responsible for many types of dystonia.
methodsA literature review was conducted focusing on evolving concepts in dystonia genetics, anatomy and physiology.
resultsThe list of genes related to dystonia has grown from a relatively small number to more than 100. Concepts regarding the neuroanatomical basis for dystonia have evolved from a relatively narrow focus on dysfunction of the basal ganglia to a broader motor network model in which the basal ganglia, cerebellum, cerebral cortex, and other brain regions play a key role. Physiologically, our understanding of the core abnormalities has matured; and numerous changes in neural signaling have been revealed in the basal ganglia, cerebellum and cortex.
conclusionAlthough the dystonias share certain clinical aspects such as over-contraction of muscles leading to abnormal movements and postures, they actually comprise a very clinically and etiologically heterogeneous group of disorders. Understanding their neurobiological basis is important for devising rational therapies appropriately targeted for specific subgroups of patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.