ArticleBMC gastroenterology2017
Oral soft tissue disorders are associated with gastroesophageal reflux disease: retrospective study.
Article in BMC gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Relationship Between Laryngopharyngeal Reflux, Gastroesophageal Reflux Disease, and Dental Erosion in Adult Populations: A Systematic Review.Digestive diseases and sciences · 2025Pooled it
- Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review.PloS one · 2020Pooled it
- Association between gastroesophageal reflux and bruxism: a scoping and bibliometric review.Brazilian oral research · 2026Article
- Association between gastroesophageal reflux disease and DMFT index in the PERSIAN Guilan Cohort Study.Scientific reports · 2025Article
- Management of Dental Demineralization in a Patient with Complex Medical Conditions: A Case Report and Clinical Outcomes.Reports (MDPI) · 2025Article
- Development and Evaluation of Gelatin-Based Gummy Jellies Enriched with Oregano Oil: Impact on Functional Properties and Controlled Release.Foods (Basel, Switzerland) · 2025Article
- Pathogenesis of pepsin-induced gastroesophageal reflux disease with advanced diagnostic tools and therapeutic implications.Frontiers in medicine · 2025Review
- Microbial functional pathways based on metatranscriptomic profiling enable effective saliva-based health assessments for precision wellness.Computational and structural biotechnology journal · 2024Article
- The oral microbiome and oral and upper gastrointestinal diseases.Journal of oral microbiology · 2024Review
- The Link between Periodontal Disease and Asthma: How Do These Two Diseases Affect Each Other?Journal of clinical medicine · 2023Review
- Dental evaluation is helpful in the differentiation of functional heartburn and gastroesophageal reflux disease.World journal of gastroenterology · 2023Article
- Xerogenic medications may contribute to decreased unstimulated salivary flow in patients with oral burning and/or gastro-esophageal reflux disease.Frontiers in dental medicine · 2023Article
- Article
- Gut Bless Your Pain-Roles of the Gut Microbiota, Sleep, and Melatonin in Chronic Orofacial Pain and Depression.Biomedicines · 2022Review
- Article
- Exploring the causal relationship between gastroesophageal reflux and oral lesions: A mendelian randomization study.Frontiers in genetics · 2022Article
- Gastroesophageal reflux disease and oral symptoms: A two-sample Mendelian randomization study.Frontiers in genetics · 2022Article
- Evaluation of the Behavior of Two CAD/CAM Fiber-Reinforced Composite Dental Materials by Immersion Tests.Materials (Basel, Switzerland) · 2021Article
- Experimental Study Regarding the Behavior at Different pH of Two Types of Co-Cr Alloys Used for Prosthetic Restorations.Materials (Basel, Switzerland) · 2021Article
- Salivary microbiome with gastroesophageal reflux disease and treatment.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDental erosion (DE), one of oral hard tissue diseases, is one of the extraoesophageal symptoms defined as the Montreal Definition and Classification of gastroesophageal reflux disease (GERD). However, no study evaluated the relationship between GERD and oral soft tissues. We hypothesized that oral soft tissue disorders (OSTDs) would be related to GERD. The study aimed to investigate the association OSTDs and GERD.
methodsGERD patients (105 cases), older and younger controls (25 cases each) were retrospectively examined for oral symptoms, salivary flow volume (Saxon test), swallowing function (repetitive saliva swallowing test [RSST]), teeth (decayed, missing, and filled [DMF] indices), and soft tissues (as evaluation of OSTDs, gingivitis; papillary, marginal, and attached [PMA] gingival indexes, simplified oral hygiene indices [OHI-S], and inflammatory oral mucosal regions). Clinical histories, which included body mass index [BMI], the existence of alcohol and tobacco use, and bruxism, were also investigated. A P value of <0.05 was defined as statistically significant.
resultsGERD patients, older and younger controls participated and aged 66.4 ± 13.0, 68.3 ± 8.2 and 28.7 ± 2.6 years old, respectively. The most common oral symptom in the GERD patients was oral dryness. Salivary flow volume and swallowing function in the GERD patients were significantly lower than in either of the controls (all P < 0.05). Inflammatory oral mucosal regions were found only in the GERD patients. The DMF indices, as a measure of dental caries, in the GERD patients were higher than in the younger controls (P < 0.001), but lower than in the older controls (P = 0.033). The PMA gingival indexes, as a measurement for gingival inflammation, and OHI-S, as a measure for oral hygiene, in the GERD patients were significantly higher than in either of the controls (all P < 0.05). Though no significant differences in BMI, the existence of alcohol and tobacco use were found, bruxism, as an exacerbation factor of periodontal disease, in the GERD patients was significantly more frequent than in either control group (P = 0.041).
conclusionsOSTDs were associated with GERD, which was similar to the association between DE and GERD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.