ArticlePloS one2017
SnRK1 activates autophagy via the TOR signaling pathway in Arabidopsis thaliana.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
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Who cites it
103 citing papers in PubMed, 197 citations in OpenAlex.
- Review
- Beyond parallel pathways: molecular integration and functional crosstalk between autophagy and endocytosis in plants.Protoplasma · 2026Review
- Dynamic regulation of proteostasis underlies thermopriming-mediated acquired thermotolerance in Arabidopsis.Plant communications · 2026Article
- Autophagy in plants: molecular mechanisms and roles in abiotic stress responses.Frontiers in plant science · 2026Review
- Decoding the sugar-strigolactone crosstalk: new frontier in plant growth and stress resilience.Horticulture research · 2026Article
- Navigating heavy metal stress: emerging roles of TOR and SnRK signaling in plant tolerance.Frontiers in plant science · 2026Review
- Loss of the plastidial signaling molecule, ppGpp, accumulation alters nuclear gene expression during nitrogen starvation.Frontiers in plant science · 2026Article
- Autophagy-phytohormone crosstalk: a dual-regulation axis in plant development.Frontiers in plant science · 2026Review
- Epigenetic and Epitranscriptomic Antiviral Responses in Plants for Disease Management.Viruses · 2025Review
- Raffinose induces autophagy to promote the growth of Arabidopsis Thaliana.BMC plant biology · 2025Article
- Physcomitrium patens: an emerging model for autophagy study.Protoplasma · 2025Review
- Autophagy-Mediated Adaptation: Revealing the Role of Autophagy in Plant Responses to Abiotic Stress.Genes · 2025Review
- Review
- SlATG8f coordinates ethylene signaling and chloroplast turnover to drive tomato fruit ripening.Plant cell reports · 2025Article
- The ABAP1 interacting protein 10 (AIP10) exerts a dual role in the cell cycle and primary metabolism pathways in Arabidopsis thaliana.The Plant journal : for cell and molecular biology · 2025Article
- Rapamycin-Reactivated Lipid Catabolism inCells · 2025Article
- V-ATPases and amino acid catabolism are strongly disturbed in the roots of autophagy mutants in Arabidopsis, impacting water use efficiency and tricarboxylic acid metabolism.The Plant journal : for cell and molecular biology · 2025Article
- TOR Mediates Stress Responses Through Global Regulation of Metabolome in Plants.International journal of molecular sciences · 2025Review
- Review
- Seed-specific expression of AtWRI1 enhanced the yield of cotton seed oil.Scientific reports · 2024Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy is a degradation process in which cells break down and recycle their cytoplasmic contents when subjected to environmental stress or during cellular remodeling. The Arabidopsis thaliana SnRK1 complex is a protein kinase that senses changes in energy levels and triggers downstream responses to enable survival. Its mammalian ortholog, AMPK, and yeast ortholog, Snf-1, activate autophagy in response to low energy conditions. We therefore hypothesized that SnRK1 may play a role in the regulation of autophagy in response to nutrient or energy deficiency in Arabidopsis. To test this hypothesis, we determined the effect of overexpression or knockout of the SnRK1 catalytic subunit KIN10 on autophagy activation by abiotic stresses, including nutrient deficiency, salt, osmotic, oxidative, and ER stress. While wild-type plants had low basal autophagy activity in control conditions, KIN10 overexpression lines had increased autophagy under these conditions, indicating activation of autophagy by SnRK1. A kin10 mutant had a basal level of autophagy under control conditions similar to wild-type plants, but activation of autophagy by most abiotic stresses was blocked, indicating that SnRK1 is required for autophagy induction by a wide variety of stress conditions. In mammals, TOR is a negative regulator of autophagy, and AMPK acts to activate autophagy both upstream of TOR, by inhibiting its activity, and in a parallel pathway. Inhibition of Arabidopsis TOR leads to activation of autophagy; inhibition of SnRK1 did not block this activation. Furthermore, an increase in SnRK1 activity was unable to induce autophagy when TOR was also activated. These results demonstrate that SnRK1 acts upstream of TOR in the activation of autophagy in Arabidopsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.