ArticleScience immunology2017
Constitutive resistance to viral infection in human CD141
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 103 citations in OpenAlex.
- Noncanonical Transcription and Splicing Shape the Colorectal Cancer Immunopeptidome in MSI and MSS Tumors.Molecular & cellular proteomics : MCP · 2026Article
- Transcriptomic Signatures of Immune Suppression and Cellular Dysfunction Distinguish Latent from Transcriptionally Active HIV-1 Infection in Dendritic Cells.International journal of molecular sciences · 2026Article
- Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells.Nature immunology · 2025Article
- Dendritic cells and HIV transmission: roles and subsets of antigen-presenting cells in the human anogenital tract.PLoS pathogens · 2025Review
- Plasmacytoid dendritic cell sensing of hepatitis E virus is shaped by both viral and host factors.Life science alliance · 2025Article
- Recent Advances in Our Understanding of Human Inflammatory Dendritic Cells in Human Immunodeficiency Virus Infection.Viruses · 2025Review
- The role of plasmacytoid dendritic cells (pDCs) in immunity during viral infections and beyond.Cellular & molecular immunology · 2024Review
- BamQuery: a proteogenomic tool to explore the immunopeptidome and prioritize actionable tumor antigens.Genome biology · 2023Article
- XCR1 expression distinguishes human conventional dendritic cell type 1 with full effector functions from their immediate precursors.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- RELA tunes innate-like interferon I/III responses in human T cells.The Journal of experimental medicine · 2023Article
- Magnitude and kinetics of the human immune cell response associated with severe dengue progression by single-cell proteomics.Science advances · 2023Article
- Different routes of MHC-I delivery to phagosomes and their consequences to CD8 T cell immunity.Seminars in immunology · 2023Review
- Article
- IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses.Nature communications · 2022Article
- Lessons in self-defence: inhibition of virus entry by intrinsic immunity.Nature reviews. Immunology · 2022Review
- Metabolomic and lipidomic signatures associated with activation of human cDC1 (BDCA3Immunology · 2022Article
- Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).European journal of immunology · 2021Review
- Long noncoding RNA MIR4435-2HG enhances metabolic function of myeloid dendritic cells from HIV-1 elite controllers.The Journal of clinical investigation · 2021Article
- Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.The EMBO journal · 2021Article
- TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming.Nature immunology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 7 institutions in 3 countries.
Aymeric SilvinImmunity and Cancer Department, Institut Curie, PSL Research University, INSERM U932, 75005 Paris, France.ORCID http://orcid.org/0000-0003-2748-8555
Chun I YuBaylor Institute for Immunology Research, Dallas, TX 75204, USA.ORCID http://orcid.org/0000-0002-4304-2177
Xavier LahayeImmunity and Cancer Department, Institut Curie, PSL Research University, INSERM U932, 75005 Paris, France.ORCID http://orcid.org/0000-0001-7124-1707
Francesco ImperatoreCentre d'Immunologie de Marseille-Luminy, Aix Marseille University, UM2, INSERM U1104, CNRS UMR7280, France.ORCID http://orcid.org/0000-0001-5883-4727
Jean-Baptiste BraultInstitut Curie, PSL Research University, CNRS, UMR144, Molecular Mechanisms of Intracellular Transport, 75005 Paris, France.
Sylvain CardinaudCentre d'Immunologie et des Maladies Infectieuses-Paris, Pierre and Marie Curie University UMRS C7, INSERM U1135, CNRS ERL 8255, Paris, France.ORCID http://orcid.org/0000-0002-2650-1108
Christian BeckerDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine; and Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
Wing-Hong KwanDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID http://orcid.org/0000-0002-1281-3995
Cécile ConradImmunity and Cancer Department, Institut Curie, PSL Research University, INSERM U932, 75005 Paris, France.ORCID http://orcid.org/0000-0002-8779-6819
Mathieu MaurinImmunity and Cancer Department, Institut Curie, PSL Research University, INSERM U932, 75005 Paris, France.ORCID http://orcid.org/0000-0003-3555-6247
Christel GoudotImmunity and Cancer Department, Institut Curie, PSL Research University, INSERM U932, 75005 Paris, France.
Santy Marques-LadeiraImmunity and Cancer Department, Institut Curie, PSL Research University, INSERM U932, 75005 Paris, France.ORCID http://orcid.org/0000-0002-7580-4957
Yuanyuan WangBaylor Institute for Immunology Research, Dallas, TX 75204, USA.
Virginia PascualBaylor Institute for Immunology Research, Dallas, TX 75204, USA.ORCID http://orcid.org/0000-0002-2274-7979
Esperanza AnguianoBaylor Institute for Immunology Research, Dallas, TX 75204, USA.ORCID http://orcid.org/0000-0002-4530-7239
Randy A AlbrechtDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID http://orcid.org/0000-0003-4008-503X
Matteo IannaconeDivision of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID http://orcid.org/0000-0002-9370-2671
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID http://orcid.org/0000-0002-6551-1827
Bruno GoudInstitut Curie, PSL Research University, CNRS, UMR144, Molecular Mechanisms of Intracellular Transport, 75005 Paris, France.ORCID http://orcid.org/0000-0003-1227-4159
Marc DalodCentre d'Immunologie de Marseille-Luminy, Aix Marseille University, UM2, INSERM U1104, CNRS UMR7280, France.ORCID http://orcid.org/0000-0002-6436-7966
Arnaud MorisCentre d'Immunologie et des Maladies Infectieuses-Paris, Pierre and Marie Curie University UMRS C7, INSERM U1135, CNRS ERL 8255, Paris, France.ORCID http://orcid.org/0000-0002-5052-1678
Miriam MeradPrecision Immunology Institute, Human Immune Monitoring Center, Tisch Cancer institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID http://orcid.org/0000-0002-4481-7827
A Karolina PaluckaBaylor Institute for Immunology Research, Dallas, TX 75204, USA. karolina.palucka@jax.org nicolas.manel@curie.fr.ORCID http://orcid.org/0000-0002-1600-6066
Nicolas ManelImmunity and Cancer Department, Institut Curie, PSL Research University, INSERM U932, 75005 Paris, France. karolina.palucka@jax.org nicolas.manel@curie.fr.ORCID http://orcid.org/0000-0002-1481-4430
Inserm · FRCentre National de la Recherche Scientifique · FRBaylor University · USIcahn School of Medicine at Mount Sinai · USMount Sinai Hospital · USTisch Hospital · USVita-Salute San Raffaele University · IT
Funding
Targeting Dendritic Cells for Enhanced Musocal ImmunityU19AI057234 · NIAID · BAYLOR RESEARCH INSTITUTE · PI ZURAWSKI, GERARD · 2003 to 2013
$49.2MProject 3 - Ex vivo immune profiling of dengue viruses and vaccinesU19AI118610 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KASARSKIS, ANDREW · 2015 to 2021
$46.6MVaccine Induced Activation of T Follicular Helper Cell SubsetsU19AI089987 · NIAID · BAYLOR RESEARCH INSTITUTE · PI PASCUAL, MARIA VIRGINIA · 2010 to 2015
$17.0MProject I: Immunity to Influenza in Primary Lung Epithelial CellsU19AI117873 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAYOT, FERNAND · 2015 to 2019
$8.6MERK control of Dendritic Cell Differentiation, Homeostasis and DiseaseR01CA154947 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CARL E ALLEN, MIRIAM MERAD · 2011 to 2026
$7.0MA Systems-level Approach to Studying HIV/AIDS Susceptibility and Substance AbuseR01DA033773 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 2012 to 2016
$4.6MContribution of the cutaneous APC network to melanoma progression and therapy.R01CA173861 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MERAD, MIRIAM · 2013 to 2017
$2.1MRole of Mucosal DC Subsets in the Control of Influenza A Virus ImmunityU01AI095611 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MERAD, MIRIAM, PALUCKA, ANNA KAROLINA · 2011 to 2015
$1.8MNCI NIH HHS R01 CA154947NCI NIH HHS R01 CA173861NIAID NIH HHS HHSN272201400008CNIAID NIH HHS U01 AI095611NIAID NIH HHS U19 AI057234NIAID NIH HHS U19 AI089987NIAID NIH HHS U19 AI117873NIAID NIH HHS U19 AI118610NIDA NIH HHS R01 DA033773
Abstract
Dendritic cells (DCs) are critical for the launching of protective T cell immunity in response to viral infection. Viruses can directly infect DCs, thereby compromising their viability and suppressing their ability to activate immune responses. How DC function is maintained in light of this paradox is not understood. By analyzing the susceptibility of primary human DC subsets to viral infections, we report that CD141
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.