ArticleScience immunology2016
Characterization of T and B cell repertoire diversity in patients with RAG deficiency.
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 110 citations in OpenAlex.
- Peripheral B-cell receptor immunoglobulin heavy chain repertoire as a potential biomarker for frequently relapsing nephrotic syndrome in children.Renal failure · 2026Article
- Updated EBMT/ESID inborn errors working party guidelines for haematopoietic stem cell transplantation for inborn errors of immunity and metabolism.Bone marrow transplantation · 2026Review
- SatTCR: a pipeline for performing saturation analysis of the T cell receptor repertoire and a case study of a healthy canine.MethodsX · 2026Article
- Comprehensive Profiling of T- and B-Cell Receptor Repertoires Demonstrates Impaired Developmental and Activation of Adaptive Immunity in DOCK8 Deficiency.Journal of clinical immunology · 2026Article
- Dominant-negative PSMB10 disrupts immunoproteasome assembly and leads to transient T lymphopenia.Journal of human immunity · 2026Article
- Unfavourable H-CDR3 Loops in preB Cells Lead to Highly Expanded Plasma Cell Clones.European journal of immunology · 2026Article
- Priming versus propagating: distinct immune effects of alpha- versus beta-particle emitting radiopharmaceuticals when combined with immune checkpoint inhibition in mice.Nature communications · 2026Article
- Immunorepertoire-based characterization of adaptive immunity in human malignant pleural effusion.Frontiers in oncology · 2026Article
- A High-Throughput Sequencing Strategy for Clinical Repertoire Profiling of T Cell Receptor Beta Chain: Development and Reference Values Across Healthy Adults, Paediatrics, and Cord Blood Units.International journal of molecular sciences · 2025Article
- Comprehensive αβ T-Cell Receptor Repertoire Analysis Reveals a Unique CD8+ TCR Landscape in DOCK8-Deficient Patients.Allergy · 2025Article
- Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency.The Journal of experimental medicine · 2025Article
- Factors associated with and kinetics of anti-IFN-α autoantibodies inThe journal of allergy and clinical immunology. Global · 2025Article
- A single-cell V(D)J sequencing dataset of peripheral blood cells in multibacillary leprosy.Scientific data · 2025Article
- Replication stress, microcephalic primordial dwarfism, and compromised immunity in ATRIP deficient patients.The Journal of experimental medicine · 2025Article
- Age-Related Dynamics and Spectral Characteristics of the TCRβ Repertoire in Healthy Children: Implications for Immune Aging.Aging cell · 2025Article
- To cleave or not and how? The DNA exonucleases and endonucleases in immunity.Genes & diseases · 2025Review
- Evaluation of T-cell repertoire by flow cytometric analysis in primary immunodeficiencies with DNA repair defects.Scandinavian journal of immunology · 2025Article
- Review
- IL7 in combination with radiotherapy stimulates a memory T-cell response to improve outcomes in HNSCC models.Cancer immunology, immunotherapy : CII · 2024Article
- Comprehensive characterization and database construction of immune repertoire in the largest Chinese glioma cohort.iScience · 2024Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors at 13 institutions in 7 countries.
Yu Nee LeeDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Francesco FrugoniDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Kerry DobbsLaboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Irit TiroshDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Likun DuDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Francesca A VerversDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Heng RuDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Lisa Ott de BruinDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Mehdi AdeliPediatrics Department, Weill Cornell Medical College, Hamad Medical Corporation, Doha, Qatar.
Jacob H BleesingDivision of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
David BuchbinderDivision of Hematology, Children's Hospital Orange County, Orange County, CA 92868, USA.
Manish J ButteDivision of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.
Caterina CancriniDPUO, University Department of Pediatrics, Bambino Gesù Children's Hospital and University of Tor Vergata School of Medicine, Rome, Italy.
Karin ChenDivision of Allergy, Immunology, and Rheumatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA.
Sharon ChooDepartment of Immunology, Royal Children's Hospital, Melbourne, Victoria, Australia.
Reem A ElfekyDepartment of Pediatric Allergy and Immunology, Children's Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Andrea FinocchiDPUO, University Department of Pediatrics, Bambino Gesù Children's Hospital and University of Tor Vergata School of Medicine, Rome, Italy.
Ramsay L FuleihanDivision of Allergy and Immunology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Andrew R GenneryDepartment of Paediatric Immunology, Great North Children's Hospital, Newcastle Upon Tyne, U.K.
Dalia H El-GhoneimyDepartment of Pediatric Allergy and Immunology, Children's Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Lauren A HendersonDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Waleed Al-HerzDepartment of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
Elham HossnyDepartment of Pediatric Allergy and Immunology, Children's Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Robert P NelsonDivision of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Sung-Yun PaiDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.
Niraj C PatelDivision of Infectious Disease and Immunology, Department of Pediatrics, Levine Children's Hospital, Carolinas Medical Center, Charlotte, NC 28203, USA.
Shereen M RedaDepartment of Pediatric Allergy and Immunology, Children's Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Pere Soler-PalacinPaediatric Infectious Diseases and Immunodeficiencies Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
Raz SomechPediatric Department A and the Immunology Service, "Edmond and Lily Safra" Children's Hospital, Jeffrey Modell Foundation Center, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Paolo PalmaDPUO, University Department of Pediatrics, Bambino Gesù Children's Hospital and University of Tor Vergata School of Medicine, Rome, Italy.
Hao WuDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Silvia GilianiA. Nocivelli Institute for Molecular Medicine, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Jolan E WalterDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Luigi D NotarangeloLaboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. luigi.notarangelo2@nih.gov.
Boston Children's Hospital · USAin Shams University Hospital · EGBambino Gesù Children's Hospital · ITHarvard University · USEdmond and Lily Safra Children's Hospital · ILIndiana University School of MedicineKuwait University · KWNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · USRoyal Children's Hospital · AUSheba Medical Center · ILUniversity of Brescia · ITVall d'Hebron Hospital Universitari · ES
Funding
Training of Clinical Investigators in Primary Immune DeficienciesU54AI082973 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PUCK, JENNIFER M. · 2009 to 2023
$23.3MCharacterization of the cellular and molecular bases of inborn errors of immunityZIAAI001222 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2017 to 2025
$15.2MJoint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4MModeling and correcting human SCID using patient-derived iPS cellsR01AI100887 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI MANIS, JOHN P · 2012 to 2020
$4.5MMolecular mechanisms of the RAG recombinase in V(D)J recombination and diseaseR01AI125535 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WU, HAO · 2016 to 2020
$3.2MAutoimmunity in Rag Deficiency: A Nexus of Immunodeficiency and DysregulationK08AI103035 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI WALTER, JOLAN ESZTER · 2012 to 2016
$683kIntramural NIH HHS Z99 AI999999NIAID NIH HHS K08 AI103035NIAID NIH HHS R01 AI100887NIAID NIH HHS R01 AI125535NIAID NIH HHS U54 AI082973NIAMS NIH HHS L40 AR065238NIAMS NIH HHS P30 AR070253
Abstract
Recombination-activating genes 1 and 2 (
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.