ArticleScience immunology2017
The checkpoint for agonist selection precedes conventional selection in human thymus.
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Article in Science immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
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Who cites it
37 citing papers in PubMed, 57 citations in OpenAlex.
- Analysis of Human Thymopoiesis Reveals Rapid Postnatal Remodeling of Thymocytes Within the First 3 Months of Life.European journal of immunology · 2026Article
- Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets.Nature communications · 2025Article
- Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease.Signal transduction and targeted therapy · 2025Review
- Diverse modes of T cell receptor sequence convergence define unique functional and cellular phenotypes.bioRxiv : the preprint server for biology · 2025Article
- Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes.bioRxiv : the preprint server for biology · 2025Article
- Decoding thymic development: a single-cell atlas of tree shrew immunity.Frontiers in immunology · 2025Article
- ThymoSpheres culture: A model to study human polyclonal unconventional T cells.European journal of immunology · 2024Article
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- Intraepithelial Lymphocytes of the Intestine.Annual review of immunology · 2024Review
- Cancer immunity by tissue-resident type 1 innate lymphoid cells and killer innate-like T cells.Immunological reviews · 2024Review
- Human thymic putative CD8αα precursors exhibit a biased TCR repertoire in single cell AIRR-seq.Scientific reports · 2023Article
- CD1b glycoprotein, a crucial marker of thymocyte development during T cell maturation in cynomolgus monkeys.Scientific reports · 2023Article
- Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells.Science immunology · 2023Article
- Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage.The Journal of experimental medicine · 2023Article
- TGF-β Regulation of T Cells.Annual review of immunology · 2023Review
- Autoimmune uveitis in Behçet's disease and Vogt-Koyanagi-Harada disease differ in tissue immune infiltration and T cell clonality.Clinical & translational immunology · 2023Article
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- The perception and response of T cells to a changing environment are based on the law of initial value.Science signaling · 2022Review
- Bcl-2 Is Necessary to Counteract Bim and Promote Survival of TCRαβJournal of immunology (Baltimore, Md. : 1950) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 5 institutions in 2 countries.
Greet VerstichelFaculty of Medicine and Health Sciences, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, 9000 Ghent, Belgium.ORCID http://orcid.org/0000-0001-9195-4392
David VermijlenDepartment of Biopharmacy, Université Libre de Bruxelles (ULB), Boulevard du Triomphe, accès 2, 1050 Brussels, Belgium.ORCID http://orcid.org/0000-0002-7605-8845
Liesbet MartensData Mining and Modeling for Systems Immunology, Vlaams Instituut voor Biotechnologie Inflammation Research Center, Technologiepark 927, 9052 Ghent, Belgium.
Glenn GoetgelukFaculty of Medicine and Health Sciences, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, 9000 Ghent, Belgium.
Margreet BrouwerInstitute for Medical Immunology, ULB, Rue Adrienne Bolland 8, 6041 Gosselies, Belgium.
Nicolas ThiaultDivision of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Yasmine Van CaeneghemFaculty of Medicine and Health Sciences, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, 9000 Ghent, Belgium.
Stijn De MunterFaculty of Medicine and Health Sciences, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, 9000 Ghent, Belgium.ORCID http://orcid.org/0000-0003-3821-0620
Karin WeeningFaculty of Medicine and Health Sciences, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, 9000 Ghent, Belgium.
Sarah BonteFaculty of Medicine and Health Sciences, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, 9000 Ghent, Belgium.ORCID http://orcid.org/0000-0002-0637-4893
Georges LeclercqFaculty of Medicine and Health Sciences, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, 9000 Ghent, Belgium.
Tom TaghonFaculty of Medicine and Health Sciences, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, 9000 Ghent, Belgium.ORCID http://orcid.org/0000-0002-5781-0288
Tessa KerreFaculty of Medicine and Health Sciences, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, 9000 Ghent, Belgium.ORCID http://orcid.org/0000-0003-2114-2844
Yvan SaeysData Mining and Modeling for Systems Immunology, Vlaams Instituut voor Biotechnologie Inflammation Research Center, Technologiepark 927, 9052 Ghent, Belgium.ORCID http://orcid.org/0000-0002-0415-1506
Jo Van DorpeFaculty of Medicine and Health Sciences, Department of Medical and Forensic Pathology, Ghent University, University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium.ORCID http://orcid.org/0000-0001-8175-2930
Hilde CheroutreDivision of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Bart VandekerckhoveFaculty of Medicine and Health Sciences, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, 9000 Ghent, Belgium. bart.vandekerckhove@ugent.be.ORCID http://orcid.org/0000-0003-3828-4195
Ghent University Hospital · BELa Jolla Institute for Immunology · USInstitute of Pathology and Genetics · BEUniversité Libre de Bruxelles · BEVlaams Instituut voor Biotechnologie · BE
Funding
Selective Instructions for Memory T CellsR01AI064584 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CHEROUTRE, HILDE MC · 2005 to 2015
$4.5MUncovering the Missing Link that Determines Susceptibility to AutoimmunityDP1GM105384 · NIGMS · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CHEROUTRE, HILDE MC · 2012 to 2013
$1.8MNIAID NIH HHS R01 AI064584NIGMS NIH HHS DP1 GM105384
Abstract
The thymus plays a central role in self-tolerance, partly by eliminating precursors with a T cell receptor (TCR) that binds strongly to self-antigens. However, the generation of self-agonist-selected lineages also relies on strong TCR signaling. How thymocytes discriminate between these opposite outcomes remains elusive. Here, we identified a human agonist-selected PD-1
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