Evidence map›Paper›PMID 28783670›Full record

ArticleScience immunology2017

Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation.

Denise Lau, Linda Yu-Ling Lan, Sarah F Andrews, Carole Henry, Karla Thatcher Rojas, Karlynn E Neu, Min Huang, Yunping Huang, Brandon DeKosky, Anna-Karin E Palm and 3 more

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 268 citations in OpenAlex.

  1. Trial
  2. Elevated CD21Journal of clinical immunology · 2022
    Trial
  3. Trial
  4. Trial
  5. The Antigen Presenting Potential of CD21Frontiers in immunology · 2020
    Trial
  6. Article
  7. Article
  8. Review
  9. Review
  10. Human CD21Journal of human immunity · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Denise LauCommittee on Immunology, University of Chicago, Chicago, IL 60615, USA.
Linda Yu-Ling LanCommittee on Immunology, University of Chicago, Chicago, IL 60615, USA.
Sarah F AndrewsDepartment of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60615, USA.
Carole HenryDepartment of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60615, USA.
Karla Thatcher RojasDepartment of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60615, USA.
Karlynn E NeuCommittee on Immunology, University of Chicago, Chicago, IL 60615, USA.
Min HuangDepartment of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60615, USA.
Yunping HuangDepartment of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60615, USA.
Brandon DeKoskyDepartment of Chemical Engineering, University of Texas at Austin, Austin, TX 78731, USA.
Anna-Karin E PalmDepartment of Medicine, Section of Rheumatology, Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60615, USA.
Gregory C IppolitoDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78731, USA.
George GeorgiouDepartment of Chemical Engineering, University of Texas at Austin, Austin, TX 78731, USA.
Patrick C WilsonCommittee on Immunology, University of Chicago, Chicago, IL 60615, USA. wilsonp@uchicago.edu.
The University of Texas at Austin · US

Funding

VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7M
Toward a Universal Influenza Virus VaccineP01AI097092 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2012 to 2022
$17.6M
Understanding Human B Cell Responses to Influenza to Improve the Influenza U19AI109946 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RAVETCH, JEFFREY VICTOR · 2014 to 2018
$9.6M
University of Chicago Autoimmunity Center of ExcellenceU19AI082724 · NIAID · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 2009 to 2023
$7.2M
NIAID NIH HHS HHSN272201400006CNIAID NIH HHS P01 AI097092NIAID NIH HHS U19 AI057266NIAID NIH HHS U19 AI082724NIAID NIH HHS U19 AI109946
6 · The paper itself

Abstract

In this study, we report that antigen-specific CD19

Identifiers

PMID28783670
PMCPMC5896567
OpenAlexW2580955103

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.