Evidence map›Paper›PMID 28783527›Full record

ArticleDiabetes research and clinical practice2017

Circulating early- and mid-pregnancy microRNAs and risk of gestational diabetes.

Pandora L Wander, Edward J Boyko, Karin Hevner, Viraj J Parikh, Mahlet G Tadesse, Tanya K Sorensen, Michelle A Williams, Daniel A Enquobahrie

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes research and clinical practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 3 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 112 citations in OpenAlex.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Pandora L WanderDepartment of Medicine, University of Washington, Seattle, WA, USA; VA Puget Sound Health Care System, Seattle, WA, USA. Electronic address: lwander@u.washington.edu.
Edward J BoykoDepartment of Medicine, University of Washington, Seattle, WA, USA; VA Puget Sound Health Care System, Seattle, WA, USA.
Karin HevnerCenter for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA.
Viraj J ParikhDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Mahlet G TadesseDepartment of Mathematics and Statistics, Georgetown University, Washington, DC, USA.
Tanya K SorensenCenter for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA.
Michelle A WilliamsDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Daniel A EnquobahrieCenter for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA.
Swedish Medical Center · USUniversity of Washington · USGeorgetown University · USHarvard University · USVA Puget Sound Health Care System · US

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI ALI SHOJAIE · 1995 to 2026
$42.5M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Etiologic Heterogeneity in Preterm DeliveryR01HD034543 · NICHD · MICHIGAN STATE UNIVERSITY · PI HOLZMAN, CLAUDIA B. · 1997 to 2005
$5.3M
The Epidemiology of Marine Fatty Acids and PreeclampsiaR01HD032562 · NICHD · SWEDISH MEDICAL CENTER, FIRST HILL · PI WILLIAMS, MICHELLE A. · 1996 to 2006
$3.0M
Circulating MicroRNAs and HyperglycemiaK08DK103945 · NIDDK · UNIVERSITY OF WASHINGTON · PI JANUSZEWSKI, PANDORA LUKE · 2015 to 2019
$782k
Vitamin D related genes and developmental origins of cardiometabolic riskK01HL103174 · NHLBI · UNIVERSITY OF WASHINGTON · PI ENQUOBAHRIE, DANIEL ASMAMAW · 2010 to 2014
$661k
NHLBI NIH HHS K01 HL103174NICHD NIH HHS R01 HD032562NICHD NIH HHS R01 HD034543NIDDK NIH HHS K08 DK103945NIDDK NIH HHS P30 DK017047NIEHS NIH HHS P30 ES007033
6 · The paper itself

Abstract

aimsEpigenetic regulators, including microRNAs (miRNAs), are implicated in type 2 diabetes, but evidence linking circulating miRNAs in pregnancy and risk of gestational diabetes (GDM) is sparse. Potential modifiers, including pre-pregnancy overweight/obesity and offspring sex, are unexamined. We hypothesized that circulating levels of early-mid-pregnancy (range 7-23weeks of gestation) candidate miRNAs are related to subsequent development of GDM. We also hypothesized that miRNA-GDM associations might vary by pre-pregnancy body-mass index (ppBMI) or offspring sex.

methodsIn a case-control analysis (36GDM cases/80 controls) from the Omega study, a prospective cohort study of pregnancy complications, we measured early-mid-pregnancy plasma levels of 10miRNAs chosen for potential roles in pregnancy course and complications (miR-126-3p, -155-5p, -21-3p, -146b-5p, -210-3p, -222-3p, -223-3p, -517-5p, -518a-3p, and 29a-3p) using qRT-PCR. Logistic regression models adjusted for gestational age at blood draw (GA) were fit to compare circulating miRNAs between cases and controls. We repeated analyses among overweight/obese (ppBMI≥25kg/m

resultsMean age was 34.3years (cases) and 32.9years (controls). GA-adjusted miR-155-5p (β=0.260/p=0.028) and -21-3p (β=0.316/p=0.005) levels were positively associated with GDM. MiR-146b-5p (β=0.266/p=0.068) and miR-517-5p (β=0.196/p=0.074) were borderline. Associations of miR-21-3p and miR-210-3p with GDM were observed among overweight/obese but not lean women. Associations of six miRNAs (miR-155-5p, -21-3p, -146b-5p, -223-3p, -517-5p, and -29a-3p) with GDM were present only among women carrying male fetuses (all p<0.05).

conclusionsCirculating early-mid-pregnancy miRNAs are associated with GDM, particularly among women who are overweight/obese pre-pregnancy or pregnant with male offspring. This area has potential to clarify mechanisms underlying GDM pathogenesis and identify at-risk mothers earlier in pregnancy.

Indexed as

AdultDiabetes, GestationalDiabetes Mellitus, Type 2FemaleHumansMaleMicroRNAsObesityPregnancyPregnancy ComplicationsRiskMicroRNAsEpidemiologyEpigeneticsFetal–sex-specific disease associationsGestational diabetes mellitusMaternal pre-pregnancy overweight/obesityMicroRNAs

Identifiers

PMID28783527
PMCPMC5623075
OpenAlexW2736819442

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.