ArticleAnalytical chemistry2017
SHARPER Reaction Monitoring: Generation of a Narrow Linewidth NMR Singlet, without X-Pulses, in an Inhomogeneous Magnetic Field.
Article in Analytical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Single-scan ultra-selective probing on targeted components from overlapped NMR spectra.Magnetic resonance letters · 2026Article
- Enhancing detection of low‑abundance metabolites in proton NMR through band‑selective suppression and presaturation.Natural products and bioprospecting · 2026Article
- Line-narrowing by polychromatic selective spin-locking in NMR.Magnetic resonance (Gottingen, Germany) · 2026Article
- SHARPER-DOSY: Sensitivity enhanced diffusion-ordered NMR spectroscopy.Nature communications · 2023Article
- EnhancingACS measurement science au · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a new pure-shift method, termed SHARPER (Sensitive, Homogeneous, And Resolved PEaks in Real time) designed for the analysis of reactions and equilibria by NMR. By focusing on a single selected signal, SHARPER removes all heteronuclear couplings of a selected nucleus without the need to pulse on X channels, thus overcoming hardware limitations of conventional spectrometers. A more versatile decoupling scheme, termed sel-SHARPER, removes all heteronuclear and homonuclear couplings of the selected signal. Both methods are characterized by a periodic inversion of the active spin during the real-time acquisition. In addition to decoupling, they also compensate for pulse imperfections and magnetic field inhomogeneity, generating an extremely narrow singlet with a linewidth approaching limits dictated by the spin-spin relaxation. The decoupling and line narrowing effected by (sel)-SHARPER provide significant increases in the signal-to-noise (S/N) ratio. Increases of 20-fold were routinely achieved for
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Registered trials
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