ArticleNature genetics2017
Effect of sequence variants on variance in glucose levels predicts type 2 diabetes risk and accounts for heritability.
Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Risk of type 2 diabetes and KCNJ11 gene polymorphisms: a nested case-control study and meta-analysis.Scientific reports · 2022Pooled it
- Polygenic modeling of genetic effects on both phenotypic mean and variance: distributional regression for BMI, blood and urine biomarkers in the UK Biobank.Frontiers in bioinformatics · 2026Article
- Interactions with polygenic background impact quantitative traits in the UK Biobank.medRxiv : the preprint server for health sciences · 2025Article
- SPANature communications · 2025Article
- Potassium inwardly-rectifying channel subfamily J member 11 (KCNJ11) gene polymorphism in Egyptian type 2 diabetic patients: a single-center study.Molecular biology reports · 2024Article
- Detecting genetic effects on phenotype variability to capture gene-by-environment interactions: a systematic method comparison.G3 (Bethesda, Md.) · 2024Review
- A longitudinal genome-wide association study of bone mineral density mean and variability in the UK Biobank.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- WiSER: Robust and scalable estimation and inference of within-subject variances from intensive longitudinal data.Biometrics · 2022Article
- A quantile integral linear model to quantify genetic effects on phenotypic variability.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- GWAS of longitudinal trajectories at biobank scale.American journal of human genetics · 2022Article
- Heritability and genome-wide association analyses of fasting plasma glucose in Chinese adult twins.BMC genomics · 2020Article
- Dietary Fat and the Genetic Risk of Type 2 Diabetes.Current diabetes reports · 2019Review
- Next-Generation Sequencing Strategies.Cold Spring Harbor perspectives in medicine · 2019Review
- Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals.Scientific reports · 2019Article
- QTL Mapping on a Background of Variance Heterogeneity.G3 (Bethesda, Md.) · 2018Article
- Identifying loci affecting trait variability and detecting interactions in genome-wide association studies.Nature genetics · 2018Article
- Genotypic variability-based genome-wide association study identifies non-additive loci HLA-C and IL12B for psoriasis.Journal of human genetics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sequence variants that affect mean fasting glucose levels do not necessarily affect risk for type 2 diabetes (T2D). We assessed the effects of 36 reported glucose-associated sequence variants on between- and within-subject variance in fasting glucose levels in 69,142 Icelanders. The variant in TCF7L2 that increases fasting glucose levels increases between-subject variance (5.7% per allele, P = 4.2 × 10
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.