Evidence map›Paper›PMID 28783156›Full record

ArticleNature materials2017

Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability.

Shuoran Li, Lina R Nih, Haylee Bachman, Peng Fei, Yilei Li, Eunwoo Nam, Robert Dimatteo, S Thomas Carmichael, Thomas H Barker, Tatiana Segura

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 194 citations in OpenAlex.

  1. Article
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  14. Optimization of Vascularized Intestinal Organoid Model.Advanced healthcare materials · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Brain repair mechanisms after cell therapy for stroke.Brain : a journal of neurology · 2024
    Review
  20. Review

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Shuoran LiDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, USA.
Lina R NihDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, USA.
Haylee BachmanDepartment of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
Peng FeiSchool of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China.
Yilei LiDepartment of Electrical Engineering, University of California, Los Angeles, California 90095, USA.
Eunwoo NamDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, USA.
Robert DimatteoDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, USA.
S Thomas CarmichaelDepartment of Medicine, Neurology, University of California, Los Angeles, California 90095, USA.ORCID 0000-0002-1169-9203
Thomas H BarkerDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA.ORCID 0000-0002-3218-8111
Tatiana SeguraDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, USA.
University of California, Los Angeles · USGeorgia Institute of Technology · USUniversity of Virginia · US

Funding

VEGF Ligand Presentation and Therapeutic AngiogenesisR01NS079691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SEGURA, TATIANA · 2012 to 2024
$4.0M
Biotechnology Training in Biomedical Sciences and EngineeringT32GM067555 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GU, ZHEN · 2005 to 2019
$2.8M
NIGMS NIH HHS T32 GM067555NINDS NIH HHS R01 NS079691
6 · The paper itself

Abstract

Integrin binding to bioengineered hydrogel scaffolds is essential for tissue regrowth and regeneration, yet not all integrin binding can lead to tissue repair. Here, we show that through engineering hydrogel materials to promote α3/α5β1 integrin binding, we can promote the formation of a space-filling and mature vasculature compared with hydrogel materials that promote αvβ3 integrin binding. In vitro, α3/α5β1 scaffolds promoted endothelial cells to sprout and branch, forming organized extensive networks that eventually reached and anastomosed with neighbouring branches. In vivo, α3/α5β1 scaffolds delivering vascular endothelial growth factor (VEGF) promoted non-tortuous blood vessel formation and non-leaky blood vessels by 10 days post-stroke. In contrast, materials that promote αvβ3 integrin binding promoted endothelial sprout clumping in vitro and leaky vessels in vivo. This work shows that precisely controlled integrin activation from a biomaterial can be harnessed to direct therapeutic vessel regeneration and reduce VEGF-induced vascular permeability in vivo.

Indexed as

Blood Vessel ProsthesisCapillary PermeabilityBioprosthesisFibronectinsHumansHuman Umbilical Vein Endothelial CellsHydrogelsIntegrin alpha3Integrin alpha5beta1Tissue EngineeringFibronectinsHydrogelsIntegrin alpha3Integrin alpha5beta1ITGA3 protein, human

Identifiers

PMID28783156
PMCPMC5809173
OpenAlexW2744061893

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.