ArticleNature neuroscience2017
Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects.
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Article in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54citing papers in PubMed
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54 citing papers in PubMed, 102 citations in OpenAlex.
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- Ethopharmacological evaluation of antidepressant-like effect of serotonergic psychedelics in C57BL/6J male mice.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia.eLife · 2024Article
- Effect of antipsychotic drugs on group II metabotropic glutamate receptor expression and epigenetic control in postmortem brains of schizophrenia subjects.Translational psychiatry · 2024Article
- Characterizing defective lipid metabolism in the lateral septum of mice treated with olanzapine: implications for its side effects.Frontiers in pharmacology · 2024Article
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Authors and funding
27 authors at 6 institutions in 3 countries.
Daisuke IbiDepartment of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Mario de la Fuente RevengaDepartment of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Nebojsa KezunovicDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Carolina MuguruzaDepartment of Pharmacology, University of the Basque Country UPV/EHU, Leioa, Bizkaia, Spain.
Justin M SaundersDepartment of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Supriya A GaitondeDepartment of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
José L MorenoDepartment of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Maryum K IjazDepartment of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Vishaka SantoshDepartment of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Alexey KozlenkovDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Terrell HollowayDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jeremy SetoDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Aintzane García-BeaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Mitsumasa KuritaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Grace E MosleyDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Yan JiangDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Daniel J ChristoffelDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Luis F CalladoDepartment of Pharmacology, University of the Basque Country UPV/EHU, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0001-9941-012X
Scott J RussoDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Stella DrachevaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Juan F López-GiménezDepartment of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Yongchao GeDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Carlos R EscalanteDepartment of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
J Javier MeanaDepartment of Pharmacology, University of the Basque Country UPV/EHU, Leioa, Bizkaia, Spain.
Schahram AkbarianDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
George W HuntleyDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Javier González-MaesoDepartment of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Virginia Commonwealth University · USIcahn School of Medicine at Mount Sinai · USAllen Institute for Brain Science · USUniversity of the Basque Country · ESJames J. Peters VA Medical Center · USNew York City College of Technology · US
Funding
REPRESSIVE HISTONE AND DNA METHYLATION IN RODENT DEPRESSION MODELSP50MH096890 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TAMMINGA, CAROL A · 2012 to 2021
$20.2MStructure and function of the 5HT2A/mGluR2 complex in schizophreniaR01MH084894 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI Javier Gonzalez-Maeso · 2009 to 2026
$6.8MRole of thalamic versus cortical inputs to nucleus accumbens in stress-related disordersR01MH090264 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUSSO, SCOTT JAMES · 2011 to 2020
$4.2MNeurodevelopmental Phenotypes in MLL mutant miceR01MH104341 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM · 2015 to 2019
$2.1MRemodeling Neuronal Chromatin in Mouse Models for DepressionR01MH086509 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI AKBARIAN, SCHAHRAM · 2010 to 2014
$2.0MCdh8-dependent circuit development in autismR01MH104491 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENSON, DEANNA L, HUNTLEY, GEORGE W. · 2016 to 2020
$1.9MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9MPreclinical role of HDAC2 in mGlu2-dependent schizophrenia treatmentR01MH111940 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI GONZÁLEZ-MAESO, JAVIER · 2017 to 2021
$1.5MGABA Epigenomes in AutismR21MH103877 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DRACHEVA, STELLA · 2014 to 2015
$447kNIH HHS S10 OD018522NIMH NIH HHS P50 MH096890NIMH NIH HHS R01 MH084894NIMH NIH HHS R01 MH086509NIMH NIH HHS R01 MH090264NIMH NIH HHS R01 MH104341NIMH NIH HHS R01 MH104491NIMH NIH HHS R01 MH111940NIMH NIH HHS R21 MH103877
Abstract
Antipsychotic drugs remain the standard for schizophrenia treatment. Despite their effectiveness in treating hallucinations and delusions, prolonged exposure to antipsychotic medications leads to cognitive deficits in both schizophrenia patients and animal models. The molecular mechanisms underlying these negative effects on cognition remain to be elucidated. Here we demonstrate that chronic antipsychotic drug exposure increases nuclear translocation of NF-κB in both mouse and human frontal cortex, a trafficking event triggered via 5-HT
Indexed as
AnimalsAntipsychotic AgentsCognition DisordersFrontal LobeHEK293 CellsHistone Deacetylase 2HumansMaleMaze LearningMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutMice, TransgenicNF-kappa BSynapsesAntipsychotic AgentsHdac2 protein, mouseHistone Deacetylase 2NF-kappa B
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.