Evidence map›Paper›PMID 28783106›Full record

ReviewInternational journal of molecular sciences2017

Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications.

Dario Livio Longo, Rachele Stefania, Silvio Aime, Alexander Oraevsky

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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  18. Astrochemistry and Astrobiology: Materials Sciencein Wonderland?International journal of molecular sciences · 2019
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dario Livio LongoConsiglio Nazionale delle Ricerche (CNR), Istituto di Biostrutture e Bioimmagini, Torino 10126, Italy. dario.longo@unito.it.
Rachele StefaniaDipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università degli Studi di Torino, Torino 10126, Italy. rachele.stefania@unito.it.
Silvio AimeDipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università degli Studi di Torino, Torino 10126, Italy. silvio.aime@unito.it.
Alexander OraevskyTomoWave Laboratories, Houston, TX 77081, USA. AAO@TomoWave.com.

Funding

Optoacoustic imaging enhanced by gold nanorodsR44CA110137 · NCI · TOMOWAVE LABORATORIES, INC. · PI ORAEVSKY, ALEXANDER A · 2005 to 2009
$3.1M
Optoacoustic system for monitoring biodistribution of nanoparticles in vivo.R43ES021629 · NIEHS · TOMOWAVE LABORATORIES, INC. · PI ORAEVSKY, ALEXANDER A · 2011 to 2011
$115k
NCI NIH HHS R44 CA110137NIEHS NIH HHS R43 ES021629
6 · The paper itself

Abstract

Optoacoustic imaging emerged in early 1990s as a new biomedical imaging technology that generates images by illuminating tissues with short laser pulses and detecting resulting ultrasound waves. This technique takes advantage of the spectroscopic approach to molecular imaging, and delivers high-resolution images in the depth of tissue. Resolution of the optoacoustic imaging is scalable, so that biomedical systems from cellular organelles to large organs can be visualized and, more importantly, characterized based on their optical absorption coefficient, which is proportional to the concentration of absorbing chromophores. Optoacoustic imaging was shown to be useful in both preclinical research using small animal models and in clinical applications. Applications in the field of molecular imaging offer abundant opportunities for the development of highly specific and effective contrast agents for quantitative optoacoustic imaging. Recent efforts are being made in the direction of nontoxic biodegradable contrast agents (such as nanoparticles made of melanin) that are potentially applicable in clinical optoacoustic imaging. In order to increase the efficiency and specificity of contrast agents and probes, they need to be made smart and capable of controlled accumulation in the target cells. This review was written in recognition of the potential breakthroughs in medical optoacoustic imaging that can be enabled by efficient and nontoxic melanin-based optoacoustic contrast agents.

Indexed as

Contrast MediaDiagnostic ImagingMolecular ImagingPhotoacoustic TechniquesTheranostic NanomedicineAnimalsHumansMelaninsMolecular ProbesMultimodal ImagingNeoplasmsContrast MediaMelaninsMolecular Probescontrast agentmelaninnanoparticleoptoacoustic imagingphotoacoustic imaging

Identifiers

PMID28783106
PMCPMC5578109

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.