Evidence map›Paper›PMID 28782988›Full record

ArticlePulmonary circulation

Insights on pulmonary tumor thrombotic microangiopathy: a seven-patient case series.

Rohit Godbole, Rajan Saggar, Alexander Zider, Jamie Betancourt, William D Wallace, Robert D Suh, Nader Kamangar

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Etiology and Outcomes of Thrombotic Microangiopathies.Clinical journal of the American Society of Nephrology : CJASN · 2019
    Article
  9. Tumoral pulmonary hypertension.European respiratory review : an official journal of the European Respiratory Society · 2019
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rohit Godbole1 Division of Pulmonary and Critical Care Medicine, University of California, Irvine, CA, USA.
Rajan Saggar2 Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.
Alexander Zider2 Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-1535-7315
Jamie Betancourt3 Division of Pulmonary and Critical Care Medicine, West Los Angeles Veterans Affairs Medical Center, Los Angeles, CA, USA.
William D Wallace4 Department of Pathology and Laboratory Medicine, University of California, Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.
Robert D Suh5 Department of Radiological Sciences, University of California, Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.
Nader Kamangar2 Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.
University of California, Los Angeles · USUniversity of California, Irvine · USWest Los Angeles College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary tumor thrombotic microangiopathy (PTTM) is a disease process wherein tumor cells are thought to embolize to the pulmonary circulation causing pulmonary hypertension (PH) and death from right heart failure. Presented herein are clinical, laboratory, radiographic, and histologic features across seven cases of PTTM. Highlighted in this publication are also involvement of pulmonary venules and clinical features distinguishing PTTM from clinical mimics. We conducted a retrospective chart review of seven cases of PTTM from hospitals in the greater Los Angeles metropolitan area. Patients in this series exhibited: symptoms of cough and progressive dyspnea; PH and/or heart failure on physical exam; laboratory abnormalities of anemia, thrombocytopenia, elevated LDH, and elevated D-dimer; chest computed tomography (CT) showing diffuse septal thickening, mediastinal and hilar lymphadenopathy and nodules; elevated pulmonary artery pressures on transthoracic echocardiogram and/or right heart catheterization; and presence of malignancy. Tumor emboli and fibrocellular intimal proliferation were seen in pulmonary arterioles, while two patients had pulmonary venopathy. PTTM is a devastating disease occurring in patients with metastatic carcinoma. An early diagnosis is challenging. Understanding the clinical presentation of PTTM and distinguishing PTTM from clinical mimics may help achieve an early diagnosis and allow time for initiation of treatment.

Indexed as

chest imagingpulmonary arterial hypertensionpulmonary pathology

Identifiers

PMID28782988
PMCPMC5703123
OpenAlexW2744138009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.