Evidence map›Paper›PMID 28782975›Full record

ArticleJournal of abnormal psychology2017

Heterogeneity in development of aspects of working memory predicts longitudinal attention deficit hyperactivity disorder symptom change.

Sarah L Karalunas, Hanna C Gustafsson, Nathan F Dieckmann, Jessica Tipsord, Suzanne H Mitchell, Joel T Nigg

Abstract read
In one paragraph

Article in Journal of abnormal psychology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. How do stimulant treatments for ADHD work? Evidence for mediation by improved cognition.Journal of child psychology and psychiatry, and allied disciplines · 2018
    Trial
  5. Reproducible Temperament Profiles in Adolescents With Attention-Deficit/Hyperactivity Disorder Prospectively Predict Clinical Outcomes.Clinical psychological science : a journal of the Association for Psychological Science · 2026
    Article
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  8. Cognitive Profiles of Children with Reading Disabilities and/or ADHD.Behavioral sciences (Basel, Switzerland) · 2025
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  18. Impulsivity as key bridge symptoms in cross-sectional and longitudinal networks of ADHD and ODD.Journal of child psychology and psychiatry, and allied disciplines · 2024
    Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sarah L KaralunasDepartment of Psychiatry, Oregon Health & Science University.
Hanna C GustafssonDepartment of Psychiatry, Oregon Health & Science University.
Nathan F DieckmannSchool of Nursing, Oregon Health & Science University.
Jessica TipsordDepartment of Psychiatry, Oregon Health & Science University.
Suzanne H MitchellDepartment of Psychiatry, Oregon Health & Science University.
Joel T NiggDepartment of Psychiatry, Oregon Health & Science University.

Funding

ADHD heterogeneity, mechanisms, and risk profileR37MH059105 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 2014 to 2023
$7.0M
Brain trajectories in ADHDR01MH115357 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI FAIR, DAMIEN A, NIGG, JOEL T · 2017 to 2021
$3.8M
Neurophysiological mechanisms of cognitive and emotional control in ADHDK23MH108656 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI KARALUNAS, SARAH LYN · 2016 to 2019
$742k
NIMH NIH HHS K23 MH108656NIMH NIH HHS R01 MH115357NIMH NIH HHS R37 MH059105
6 · The paper itself

Abstract

The role of cognitive mechanisms in the clinical course of neurodevelopmental disorders is poorly understood. Attention Deficit Hyperactivity Disorder (ADHD) is emblematic in that numerous alterations in cognitive development are apparent, yet how they relate to changes in symptom expression with age is unclear. To resolve the role of cognitive mechanisms in ADHD, a developmental perspective that takes into account expected within-group heterogeneity is needed.

methodThe current study uses an accelerated longitudinal design and latent trajectory growth mixture models in a sample of children ages 7-13 years carefully characterized as with (n = 437) and without (n = 297) ADHD to (a) identify heterogeneous developmental trajectories for response inhibition, visual spatial working memory maintenance, and delayed reward discounting and (b) to assess the relationships between these cognitive trajectories and ADHD symptom change.

resultsBest-fitting models indicated multiple trajectory classes in both the ADHD and typically developing samples, as well as distinct relationships between each cognitive process and ADHD symptom change. Developmental change in response inhibition and delayed reward discounting were unrelated to ADHD symptom change, while individual differences in the rate of visual spatial working memory maintenance improvement predicted symptom remission in ADHD.

conclusionCharacterizing heterogeneity in cognitive development will be crucial for clarifying mechanisms of symptom persistence and recovery. Results here suggest working memory maintenance may be uniquely related to ADHD symptom improvement. (PsycINFO Database Record

Indexed as

AdolescentAnalysis of VarianceAttention Deficit Disorder with HyperactivityCase-Control StudiesChildFemaleHumansImpulsive BehaviorInhibition, PsychologicalMaleMemory, Short-TermNeuropsychological TestsRewardSpace Perception

Identifiers

PMID28782975
PMCPMC5657320

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.