Evidence map›Paper›PMID 28782886›Full record

SynthesisJournal of cellular and molecular medicine2018

Circulating trimethylamine N-oxide and the risk of cardiovascular diseases: a systematic review and meta-analysis of 11 prospective cohort studies.

Jiaqian Qi, Tao You, Jing Li, Tingting Pan, Li Xiang, Yue Han, Li Zhu

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

165 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  10. Trial
  11. Plasma Trimethylamine-Journal of the American Heart Association · 2023
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105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiaqian QiCyrus Tang Medical Institute, Soochow University, Suzhou, Jiangsu, China.
Tao YouCyrus Tang Medical Institute, Soochow University, Suzhou, Jiangsu, China.
Jing LiJiangsu Institute of Haematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Tingting PanCyrus Tang Medical Institute, Soochow University, Suzhou, Jiangsu, China.
Li XiangDepartment of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Yue HanJiangsu Institute of Haematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Li ZhuCyrus Tang Medical Institute, Soochow University, Suzhou, Jiangsu, China.ORCID 0000-0003-2040-294X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating trimethylamine N-oxide (TMAO), a canonical metabolite from gut flora, has been related to the risk of cardiovascular disorders. However, the association between circulating TMAO and the risk of cardiovascular events has not been quantitatively evaluated. We performed a systematic review and meta-analysis of all available cohort studies regarding the association between baseline circulating TMAO and subsequent cardiovascular events. Embase and PubMed databases were searched for relevant cohort studies. The overall hazard ratios for the developing of cardiovascular events (CVEs) and mortality were extracted. Heterogeneity among the included studies was evaluated with Cochran's Q Test and I

Indexed as

AgedAged, 80 and overCardiovascular DiseasesFemaleHumansMaleMethylaminesMiddle AgedProspective StudiesRisk FactorsMethylaminestrimethyloxaminecardiovascular eventsmeta-analysismortalitytrimethylamine N-oxide

Identifiers

PMID28782886
PMCPMC5742728

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.