ArticleHuman brain mapping2017
Combining task-related activation and connectivity analysis of fMRI data reveals complex modulation of brain networks.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of structural magnetic resonance imaging studies investigating cognitive and social activity levels in older adults.Neuroscience and biobehavioral reviews · 2018Pooled it
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- Toward Precision Post-Stroke Rehabilitation Medicine: Integrating Molecular, Imaging, and Computational Biomarkers for Functional Outcome Prediction.Journal of clinical medicine · 2025Review
- Differential Modulation of Attention by Aversive Associative and Statistical Learning in Distinct Visual Search Modes.Behavioral sciences (Basel, Switzerland) · 2025Article
- Unraveling trauma memory: Differential functional connectivity profiles of anterior and posterior hippocampus in post-traumatic stress disorder and its dissociative subtype.Neuroimage. Reports · 2025Article
- The long-term correlates of developmental stress on whole-brain functional connectivity during emotion regulation.Translational psychiatry · 2025Article
- Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- A chronometric relationship between circuits underlying learning and error monitoring in the basal ganglia and salience network.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Cerebral hyperactivation across the Alzheimer's disease pathological cascade.Brain communications · 2024Review
- Comparison of local activation, functional connectivity, and structural connectivity in the N-back task.Frontiers in neuroscience · 2024Article
- Increased interhemispheric functional connectivity during non-dominant hand movement in right-handed subjects.iScience · 2023Article
- Directed coupling in multi-brain networks underlies generalized synchrony during social exchange.NeuroImage · 2022Article
- Attention networks and the intrinsic network structure of the human brain.Human brain mapping · 2022Article
- Left Frontotemporal Region Plays a Key Role in Letter Fluency Task-Evoked Activation and Functional Connectivity in Normal Subjects: A Functional Near-Infrared Spectroscopy Study.Frontiers in psychiatry · 2022Article
- Brain-wide inferiority and equivalence tests in fMRI group analyses: Selected applications.Human brain mapping · 2021Article
- Reciprocal relations between reading skill and the neural basis of phonological awareness in 7- to 9-year-old children.NeuroImage · 2021Article
- Comparison of Food Cue-Evoked and Resting-State Functional Connectivity in Obesity.Psychosomatic medicine · 2020Article
- Specific and segregated changes to the functional connectome evoked by the processing of emotional faces: A task-based connectome study.Scientific reports · 2020Article
- A SENtence Supramodal Areas AtlaS (SENSAAS) based on multiple task-induced activation mapping and graph analysis of intrinsic connectivity in 144 healthy right-handers.Brain structure & function · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Task-related effects in functional magnetic resonance imaging (fMRI) data are usually analyzed with local activation approaches or integrative connectivity approaches, for example, by psychophysiological interaction (PPI) analysis. While both approaches are often applied to the same data set, a systematic combination of the results with a whole-brain (WB) perspective is rarely conducted and the relationship between task-dependent activation and connectivity effects is relatively unexplored. Here, we combined brain activation and graph theoretical analysis of WB-PPI results in an exemplary episodic memory data set of N = 136 healthy human participants and found regions with congruent as well as incongruent activation and connectivity changes between task and control conditions. A comparison with large-scale resting state networks showed that in congruent as well as incongruent regions task-positively modulated connections were mainly between-network connections, especially with the default mode network, while task-negatively modulated connections were mainly found within resting state networks. Over all regions, the strength of absolute activation effects was associated with the tendency to exhibit task-positive connectivity changes, mainly driven by a strong relationship in negatively activated regions. These results demonstrate that task demands lead to a complex modulation of brain networks and provide evidence that task-evoked activation and connectivity effects reflect separable and complementary information on the macroscale brain level assessed by fMRI. Hum Brain Mapp 38:5726-5739, 2017. © 2017 Wiley Periodicals, Inc.
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