Evidence map›Paper›PMID 28782800›Full record

ArticleThe British journal of surgery2017

Breast cancer recurrence after reoperation for surgical bleeding.

R N Pedersen, K Bhaskaran, U Heide-Jørgensen, M Nørgaard, P M Christiansen, N Kroman, H T Sørensen, D P Cronin-Fenton

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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  9. Evaluation of Metastasis Suppressor Genes Expression andAvicenna journal of medical biotechnology
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

R N PedersenDepartment of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.
K BhaskaranDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
U Heide-JørgensenDepartment of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.
M NørgaardDepartment of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.
P M ChristiansenBreast and Endocrine Section, Department of Surgery P, Aarhus University Hospital, Aarhus, Denmark.
N KromanDanish Breast Cancer Group, Copenhagen, Denmark.
H T SørensenDepartment of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.
D P Cronin-FentonDepartment of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-9738-2284
Aarhus University · DKAarhus University Hospital · DKLondon School of Hygiene & Tropical Medicine · GBRigshospitalet · DK

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundBleeding activates platelets that can bind tumour cells, potentially promoting metastatic growth in patients with cancer. This study investigated whether reoperation for postoperative bleeding is associated with breast cancer recurrence.

methodsUsing the Danish Breast Cancer Group database and the Danish National Patient Register (DNPR), a cohort of women with incident stage I-III breast cancer, who underwent breast-conserving surgery or mastectomy during 1996-2008 was identified. Information on reoperation for bleeding within 14 days of the primary surgery was retrieved from the DNPR. Follow-up began 14 days after primary surgery and continued until breast cancer recurrence, death, emigration, 10 years of follow-up, or 1 January 2013. Incidence rates of breast cancer recurrence were calculated and Cox regression models were used to quantify the association between reoperation and recurrence, adjusting for potential confounders. Crude and adjusted hazard ratios according to site of recurrence were calculated.

resultsAmong 30 711 patients (205 926 person-years of follow-up), 767 patients had at least one reoperation within 14 days of primary surgery, and 4769 patients developed breast cancer recurrence. Median follow-up was 7·0 years. The incidence of recurrence was 24·0 (95 per cent c.i. 20·2 to 28·6) per 1000 person-years for reoperated patients and 23·1 (22·5 to 23·8) per 1000 person-years for non-reoperated patients. The overall adjusted hazard ratio was 1·06 (95 per cent c.i. 0·89 to 1·26). The estimates did not vary by site of breast cancer recurrence.

conclusionIn this large cohort study, there was no evidence of an association between reoperation for bleeding and breast cancer recurrence.

Indexed as

AdultAgedAged, 80 and overBreast NeoplasmsDenmarkFemaleFollow-Up StudiesHumansIncidenceMastectomyMastectomy, SegmentalMiddle AgedNeoplasm Recurrence, LocalPostoperative HemorrhageRegistriesReoperation

Identifiers

PMID28782800
PMCPMC5655703
OpenAlexW2743817976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.