ArticleRespiratory physiology & neurobiology2017
Respiratory rhythm irregularity after carotid body denervation in rats.
Article in Respiratory physiology & neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Peripheral chemoreceptors sustain central chemoreflex potentiation and cardiorespiratory abnormalities in high-output heart failure.Basic research in cardiology · 2026Article
- Vasopressin Contributes to Respiratory and Cardiovascular Regulation in Spontaneously Hypertensive and Normotensive Rats.Journal of clinical medicine · 2025Article
- Cervical spinal cord hemisection impacts sigh and the respiratory reset in male rats.Physiological reports · 2024Article
- Brainstem astrocytes regulate breathing and may affect arousal state in rats.Physiology & behavior · 2024Article
- Contributions of carotid bodies, retrotrapezoid nucleus neurons and preBötzinger complex astrocytes to the COThe Journal of physiology · 2024Article
- Brainstem astrocytes regulate breathing and may affect arousal state in rats.bioRxiv : the preprint server for biology · 2023Article
- Progressive tauopathy disrupts breathing stability and chemoreflexes during presumptive sleep in mice.Frontiers in physiology · 2023Article
- Medullary astrocytes mediate irregular breathing patterns generation in chronic heart failure through purinergic P2X7 receptor signalling.EBioMedicine · 2022Article
- An open-source tool for automated analysis of breathing behaviors in common marmosets and rodents.eLife · 2022Article
- Dopamine, vocalization, and astrocytes.Brain and language · 2021Article
- Synuclein Deficiency Results in Age-Related Respiratory and Cardiovascular Dysfunctions in Mice.Brain sciences · 2020Article
- P2X3 receptor antagonism reduces the occurrence of apnoeas in newborn rats.Respiratory physiology & neurobiology · 2020Article
- Cardiorespiratory profiling reveals primary breathing dysfunction in Kcna1-null mice: Implications for sudden unexpected death in epilepsy.Neurobiology of disease · 2019Article
- Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia.Physiology (Bethesda, Md.) · 2018Review
- Astrocytes modulate brainstem respiratory rhythm-generating circuits and determine exercise capacity.Nature communications · 2018Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Respiratory activity is controlled by inputs from the peripheral and central chemoreceptors. Since overactivity of the carotid bodies, the main peripheral chemoreceptors, is linked to the pathophysiology of disparate metabolic and cardiovascular diseases, carotid body denervation (CBD) has been proposed as a potential treatment. However, long-term effects of CBD on the respiratory rhythm and regularity of breathing remain unknown. Here, we show that five weeks after bilateral CBD in rats, the respiratory rhythm was slower and less regular. Ten weeks after bilateral CBD, the respiratory frequency was not different from the sham-operated group, but the regularity of the respiratory rhythm was still reduced. Increased frequency of randomly occurring apneas is likely to be responsible for the irregular breathing pattern after CBD. These results should be taken into consideration since any treatment that reduces the stability of the respiratory rhythm might exacerbate the cardio-respiratory instability and worsen the cardiovascular outcomes.
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Registered trials
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