Evidence map›Paper›PMID 28782283›Full record

SynthesisEarly intervention in psychiatry2018

Psychosis risk screening in different populations using the Prodromal Questionnaire: A systematic review.

Mark Savill, Jennifer D'Ambrosio, Tyrone D Cannon, Rachel L Loewy

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Early intervention in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 117 citations in OpenAlex.

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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mark SavillDepartment of Psychiatry, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California.ORCID 0000-0002-4785-4885
Jennifer D'AmbrosioDepartment of Psychiatry, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California.
Tyrone D CannonDepartments of Psychology and Psychiatry, Yale University, New Haven, Connecticut.
Rachel L LoewyDepartment of Psychiatry, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California.
University of California, San Francisco · USYale University · US

Funding

CLINICAL SERVICES RESEARCH TRAINING PROGRAMT32MH018261 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaja Zabrina LeWinn, Rachel L. Loewy · 1985 to 2026
$7.0M
NIMH NIH HHS T32 MH018261
6 · The paper itself

Abstract

aimDiagnosing individuals at ultra high risk (UHR) for psychosis can improve early access to treatment, and a two-stage model utilizing self-report screening followed by a clinical interview can be accurate and efficient. However, it is currently unclear which screening cut-offs to adopt with different populations.

methodsA systematic review of diagnostic accuracy studies evaluating the Prodromal Questionnaire (PQ) as a preliminary screener for UHR and psychosis was conducted to examine screening effectiveness in different contexts. MedLine, PsycInfo, SCOPUS and ProQuest Dissertations and Abstracts databases were electronically searched, along with a review screen and citation search of key papers. Findings were summarized in a narrative synthesis.

resultsIn total, 14 diagnostic accuracy studies and 45 studies using the PQ as a screening tool for UHR and psychosis were included. In all settings, the 3 different versions of the PQ were all found to accurately identify UHR and full psychosis. Higher cut-off points were required in non-help-seeking samples, relative to general help-seeking populations, which in turn were higher than those needed in samples highly enriched with UHR participants.

conclusionThe findings support the use of the PQ as a preliminary screening tool for UHR in different settings; however, higher thresholds in lower UHR-prevalence populations are necessary to minimize false positives. Including the distress criteria, rather than just number of symptoms, may improve screening effectiveness. Different thresholds may be appropriate in different contexts depending on the importance of sensitivity vs specificity. Protocol registration: CRD42016033004.

Indexed as

Prodromal SymptomsPsychiatric Status Rating ScalesHumansPsychotic DisordersRisk FactorsSensitivity and Specificityattenuated symptomsPQschizophreniascreeningultra high risk

Identifiers

PMID28782283
PMCPMC5812357
OpenAlexW2743068947

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.