Evidence map›Paper›PMID 28782132›Full record

ArticleInternational journal of geriatric psychiatry2018

Aspirin and incident depressive symptoms: A longitudinal cohort study over 8 years.

Nicola Veronese, Ai Koyanagi, Brendon Stubbs, Marco Solmi, Michele Fornaro, Brisa S Fernandes, Christoph Mueller, Trevor Thompson, André F Carvalho, Stefania Maggi

Erratum issuedOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of geriatric psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Acetylsalicylic Acid and Mood Disorders: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 6 countries.

Nicola VeroneseNational Research Council, Neuroscience Institute, Aging Branch, Padova, Italy.ORCID 0000-0002-9328-289X
Ai KoyanagiResearch and Development Unit, Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, Barcelona, Spain.
Brendon StubbsSouth London and Maudsley NHS FoundationTrust, London, UK.
Marco SolmiInstitute for clinical Research and Education in Medicine (IREM), Padova, Italy.
Michele FornaroNew York Psychiatric Institute, Columbia University, New York, NY, USA.
Brisa S FernandesIMPACT Strategic Research Centre, School of Medicine, and Barwon Health, Deakin University, Geelong, Australia.
Christoph MuellerFaculty of Education and Health, University of Greenwich, London, UK.
Trevor ThompsonFaculty of Education and Health, University of Greenwich, London, UK.
André F CarvalhoTranslational Psychiatry Research Group, Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil.
Stefania MaggiNational Research Council, Neuroscience Institute, Aging Branch, Padova, Italy.
University of Greenwich · GBFoundation for Cardiovascular Biomedical Research and Gene and Cell Therapy · ITKing's College London · GBNeuroscience Institute · ITNew York Psychoanalytic Society and Institute · USParc Sanitari Sant Joan de Déu · ESUniversidade Federal do Ceará · BRUniversidade Federal do Rio Grande do Sul · BRUniversity of Padua · IT

Funding

DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVE-264022258N01AR022258 · NIAMS · UNIVERSITY OF CALIFORNIA SYS OFFICE/PRES · 2003 to 2003
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-264022259-264022259N01AR022259 · NIAMS · UNIVERSITY OF MARYLAND AT BALT · PI HOCHBERG, MARC C. · 2002 to 2006
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22260N01AR022260 · NIAMS · UNIVERSITY OF PITTSBURGH · PI KWOH, KENT · 2002 to 2006
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22261N01AR022261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH · PI JACKSON, REBECCA · 2002 to 2006
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CLINICAL CENTER FOR THE OSTEOARTHRITIS-264022262-264022262N01AR022262 · NIAMS · THE MEMORIAL HOSPITAL · PI ASSAF, ANNLOUISE R. · 2002 to 2006
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Department of Health ICA-CL-2017-03-001NIAMS NIH HHS N01 AR022258NIAMS NIH HHS N01 AR022259NIAMS NIH HHS N01 AR022260NIAMS NIH HHS N01 AR022261NIAMS NIH HHS N01 AR022262
6 · The paper itself

Abstract

objectiveAspirin exhibits anti-atherosclerotic and anti-inflammatory properties-two potential risk factors for depression. The relationship between aspirin use and depression, however, remains unclear. We investigated whether the aspirin use is associated with a decreased incidence of depressive symptoms in a large North American cohort.

methodsData from the Osteoarthritis Initiative dataset, a multicenter, longitudinal study on community-dwelling adults was analyzed. Aspirin use was defined through self-report in the past 30 days and confirmed by a trained interviewer. Incident depressive symptoms were defined as a score of ≥16 in the 20-item Center for Epidemiologic Studies-Depression scale.

resultsA total of 137 participants (mean age 65 y, 55.5% female) were using aspirin at baseline. Compared with 4003 participants not taking aspirin, no differences in Center for Epidemiologic Studies-Depression at baseline were evident (P = .65). After a median follow-up time of 8 years, the incidence of depressive symptoms was similar in those taking aspirin at baseline (43; 95% CI, 3-60) and in aspirin nonusers (38; 95% CI, 36-41) per 1000 y; log-rank test = 0.63). Based on Cox's regression analysis adjusted for 11 potential confounders, aspirin use was not significantly associated with the development of depressive symptoms (hazard ratio = 1.12; 95% CI, 0.78-1.62; P = .54). Adjustment for propensity scores or the use of propensity score matching did not alter the results.

conclusionOur study found that prescription of aspirin offered no significant protection against incident depressive symptoms. Whether aspirin is beneficial in a subgroup of depression with high levels of inflammation remains to be investigated in future studies.

Indexed as

AgedAnti-Inflammatory Agents, Non-SteroidalAspirinDepressive DisorderFemaleFibrinolytic AgentsHumansIncidenceLongitudinal StudiesMaleMiddle AgedProportional Hazards ModelsRegression AnalysisAnti-Inflammatory Agents, Non-SteroidalAspirinFibrinolytic Agentsaspirincohortdepressionepidemiologypsychiatrysurvey

Identifiers

PMID28782132
PMCPMC5773347
OpenAlexW2743837630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.