Evidence map›Paper›PMID 28782095›Full record

ArticleProgress in orthodontics2017

Markers in blood and saliva for prediction of orthodontically induced inflammatory root resorption: a retrospective case controlled-study.

Dilara Yashin, Oyku Dalci, Mohammed Almuzian, Jenkin Chiu, Rajiv Ahuja, Apurv Goel, M Ali Darendeliler

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Progress in orthodontics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dilara YashinDiscipline of Orthodontics, Faculty of Dentistry, University of Sydney, Sydney, Australia.
Oyku DalciDiscipline of Orthodontics, Faculty of Dentistry, University of Sydney, Sydney, Australia.
Mohammed AlmuzianDiscipline of Orthodontics, Faculty of Dentistry, University of Sydney, Sydney, Australia. dr_muzian@hotmail.com.
Jenkin ChiuDiscipline of Orthodontics, Faculty of Dentistry, University of Sydney, Sydney, Australia.
Rajiv AhujaDiscipline of Orthodontics, Faculty of Dentistry, University of Sydney, Sydney, Australia.
Apurv GoelAustralian Proteome Analysis Facility (APAF), Sydney, Australia.
M Ali DarendelilerDiscipline of Orthodontics, Faculty of Dentistry, University of Sydney, Sydney, Australia.
University of Sydney · AUAustralian Genome Research Facility · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHormonal and enzymatic factors may render certain individuals more susceptible to orthodontically induced inflammatory root resorption (OIIRR). The objectives of this study are (1) to identify biochemical key markers in blood and saliva that may be correlated to the trend of extensive OIIRR and (2) to utilise these markers to predict a susceptible patient-receiving orthodontic treatment.

methodsNine patients (mean age 23 + 2.9 years) who had moderate to severe OIIRR that assessed via orthopantomograms and met the inclusion criteria were classified as the root resorption group (RRG). Blood chemistry was evaluated using the collection of fasting blood and unstimulated saliva samples. Multiplex enzyme-linked immunosorbent assay (ELISA) arrays were used to screen blood and saliva samples for human cytokines, chemokines and several key enzymes that may play a role in root resorption following orthodontic force application. Biochemical findings from 16 matching subjects were used as the control (CG) for comparative measurements.

resultsPatients with moderate to severe OIIRR showed a significant increase in salivary cytokines including interleukin (IL) 7, IL-10, IL-12p70 and interferon-gamma (IFN-γ) level as well as a significant decrease in IL-4 level. Osteocalcin and procollagen type I N-terminal peptide (P1NP) appeared to be the only blood factors that showed a significant difference, more in the CG than the RRG.

conclusionsSaliva might be a more valuable way of measuring changes in cytokine expression than blood secondary to orthodontic treatment. Although the increased expression of pro-inflammatory and anti-inflammatory cytokines may be determinants in the development of moderate to severe OIIRR, cytokine expression may be affected by several potential inflammations in another part of the body. Future research could investigate the cause/effect relationship of different cytokines, in a larger group of patients and at different time intervals, using digital subtraction radiography techniques and microfluidic biosensors.

Indexed as

BiomarkersCase-Control StudiesCytokinesEnzyme-Linked Immunosorbent AssayForecastingHumansInflammationInterleukinsOrthodonticsRetrospective StudiesRoot ResorptionSalivaYoung AdultBiomarkersCytokinesInterleukins

Identifiers

PMID28782095
PMCPMC5602813
OpenAlexW2745285506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.