Evidence map›Paper›PMID 28782060›Full record

ArticleJournal of cytokine biology2017

Impacts of Interleukin-17 Neutralization on the Inflammatory Response in a Healing Ligament.

Anna Eb Clements, Connie S Chamberlain, Ellen M Leiferman, William L Murphy, Ray Vanderby

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cytokine biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anna Eb ClementsDepartment of Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconsin, USA.
Connie S ChamberlainDepartment of Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconsin, USA.
Ellen M LeifermanDepartment of Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconsin, USA.
William L MurphyDepartment of Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconsin, USA.
Ray VanderbyDepartment of Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconsin, USA.
University of Wisconsin–Madison · US

Funding

Modulation of the Immune System to Improve Ligament/Ligament Graft HealingR01AR059916 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI MURPHY, WILLIAM L., VANDERBY, RAY · 2010 to 2014
$1.4M
NIAMS NIH HHS R01 AR059916
6 · The paper itself

Abstract

In this study, we sought to improve ligament healing by modulating the inflammatory response after acute injury through the neutralization of Interleukin-17 (IL-17), which we hypothesized would decrease inflammatory cell infiltration and cytokine production. Administration of an Interleukin-17 neutralizing antibody (IL-17 NA) immediately following a rat medial collateral ligament (MCL) transection resulted in alterations in inflammatory cell populations and cytokine expression within the healing ligament, but did not reduce inflammation. Specifically, treatment resulted in a decrease in M2 (anti-inflammatory) macrophages, an increase in T cells, and an increase in the levels of IL-2, IL-6, and IL-12 in the MCL 7 days post injury. IL-17NA treatment, and subsequent immunomodulation, did not result in improved ligament healing, as measured by collagen composition and wound size.

Indexed as

ImmunomodulationInterleukin-17Ligament healingMedial collateral ligament

Identifiers

PMID28782060
PMCPMC5542014
OpenAlexW2611135346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.