Evidence map›Paper›PMID 28782046›Full record

ArticlePathogens & immunity2017

Circulating LOXL

Sophie Seang, Anoma Somasunderam, Maitreyee Nigalye, Ma Somsouk, Timoty W Schacker, Joyce L Sanchez, Peter W Hunt, Netanya S Utay, Jordan E Lake

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens & immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Observational
  2. ER stress genes (Frontiers in immunology · 2025
    Article
  3. Association between CD4BMC infectious diseases · 2021
    Article
  4. Circulating LOXLPathogens & immunity · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Sophie SeangPitie Salpetrière Hospital, University Pierre et Marie Curie, Paris, FRANCE and INSERM UMR-S943.
Anoma SomasunderamUniversity of Texas Medical Branch, Galveston, Texas.
Maitreyee NigalyeUniversity of Texas Medical Branch, Galveston, Texas.
Ma SomsoukUniversity of California, San Francisco, California.
Timoty W SchackerUniversity of Minnesota, Minneapolis, Minnesota.
Joyce L SanchezMayo Clinic, Rochester, Minnesota.
Peter W HuntUniversity of California, San Francisco, California.
Netanya S UtayUniversity of Texas Medical Branch, Galveston, Texas.
Jordan E LakeUniversity of Texas Health Science Center at Houston, Houston, Texas.
The University of Texas Medical Branch at Galveston · USUniversity of California, San Francisco · USInserm · FRMayo Clinic · USThe University of Texas Health Science Center at Houston · USUniversity of Minnesota System · US

Funding

Viral reservoirs and sanctuaries in HAART - treated patients: role and mechanismsU19AI096109 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVENSON, MARIO · 2011 to 2015
$29.5M
Inflammation, Fibrosis and End-Organ Disease in HIV-Infected AdultsK23AI110532 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LAKE, JORDAN E · 2014 to 2018
$937k
NIAID NIH HHS K23 AI110532NIAID NIH HHS U19 AI096109
6 · The paper itself

Abstract

backgroundIncomplete immune reconstitution may occur despite successful antiretroviral therapy (ART). Gut-associated lymphoid tissue (GALT) fibrosis may contribute via local CD4

methodsIn a cross-sectional analysis, we measured circulating fibrosis biomarker levels on cryopreserved plasma from adult HIV-infected (HIV+) SCOPE study participants on suppressive ART who also had fibrosis quantification on recto-sigmoid biopsies. Relationships among biomarker levels, clinical and demographic variables, GALT lymphoid aggregate (LA) collagen deposition, and LA CD4

resultsHIV+ aviremic participants (n = 39) were 92% male and 41% non-white, with median age 48 years, CD4

conclusionsCirculating LOXL2 levels may be a noninvasive measure of intestinal fibrosis and GALT CD4

Indexed as

fibrosisGALTHIVimmune reconstitution

Identifiers

PMID28782046
PMCPMC5542020
OpenAlexW2712089860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.