ArticleSurgical neurology international2017
Fluorescein for resection of high-grade gliomas: A safety study control in a single center and review of the literature.
Article in Surgical neurology international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Navigated Transcranial Magnetic Stimulation Motor Mapping Usefulness in the Surgical Management of Patients Affected by Brain Tumors in Eloquent Areas: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Intraoperative fluorescence diagnosis in the brain: a systematic review and suggestions for future standards on reporting diagnostic accuracy and clinical utility.Acta neurochirurgica · 2019Pooled it
- 5-ALA vs. fluorescein guided resection for high-grade gliomas: A systematic review and meta-analysis.Molecular and clinical oncology · 2026Article
- Comparative Analysis of 5-ALA and Fluorescent Techniques in High-Grade Glioma Treatment.Biomedicines · 2025Review
- Safety, efficacy, and side effects of sodium fluorescein-aided resection of glioblastoma: a quasi-experimental study.Annals of medicine and surgery (2012) · 2024Article
- Next-generation agents for fluorescence-guided glioblastoma surgery.Bioengineering & translational medicine · 2024Article
- Headlight and loupe-based fluorescein detection system in brain tumor surgery: a first-in-human experience.Journal of neurosurgical sciences · 2023Article
- Forecasting Molecular Features in IDH-Wildtype Gliomas: The State of the Art of Radiomics Applied to Neurosurgery.Cancers · 2023Review
- Maximal Safe Resection in Glioblastoma Surgery: A Systematic Review of Advanced Intraoperative Image-Guided Techniques.Brain sciences · 2023Review
- Review of Intraoperative Adjuncts for Maximal Safe Resection of Gliomas and Its Impact on Outcomes.Cancers · 2022Review
- Clinical feasibility of miniaturized Lissajous scanning confocal laser endomicroscopy for indocyanine green-enhanced brain tumor diagnosis.Frontiers in oncology · 2022Article
- Confocal laser imaging in neurosurgery: A comprehensive review of sodium fluorescein-based CONVIVO preclinical and clinical applications.Frontiers in oncology · 2022Review
- Intraoperative Ultrasound: Emerging Technology and Novel Applications in Brain Tumor Surgery.Frontiers in oncology · 2022Article
- How molecular imaging will enable robotic precision surgery : The role of artificial intelligence, augmented reality, and navigation.European journal of nuclear medicine and molecular imaging · 2021Review
- Fluorescence-Guided Surgery: A Review on Timing and Use in Brain Tumor Surgery.Frontiers in neurology · 2021Review
- Brain Mapping-Aided SupraTotal Resection (SpTR) of Brain Tumors: The Role of Brain Connectivity.Frontiers in oncology · 2021Review
- A rare diagnosis of an extraventricular neurocytoma.Surgical neurology international · 2021Article
- Indocyanine-Green for Fluorescence-Guided Surgery of Brain Tumors: Evidence, Techniques, and Practical Experience.Frontiers in surgery · 2019Article
- Development of a Simulation Model for Fluorescence-Guided Brain Tumor Surgery.Frontiers in oncology · 2019Article
- New Hope in Brain Glioma Surgery: The Role of Intraoperative Ultrasound. A Review.Brain sciences · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe importance of a complete resection of high-grade gliomas (HGGs) has been highlighted in scientific literature, in order to limit tumor recurrence and above all to improve disease-free survival rates. Several fluorescent biomarkers have been tested to improve intraoperative identification of residual tumor; 5-aminolevulinic acid (5-ALA) and fluorescein sodium (FS) are now starting to play a central role in glioma surgery. We performed a retrospective analysis on 47 patients operated for HGGs. Here we report our preliminary data.
methodsData of 47 consecutive patients with HGG have been collected in our study (25 males, 22 females; mean age: 60.3 years, range: 27-86 years). Fluorescein (5 mg/kg of body weight) was injected intravenously right after the induction of general anesthesia. A YELLOW 560 filter was used on an OPMI Pentero 900 microscope (Carl Zeiss Meditec, Oberkochen, Germany) to complete a microsurgical tumor removal. Glioma resection and quality of life were evaluated preoperative and postoperatively.
resultsGross total resection (GTR) was achieved in 53.2% (
conclusionFluorescein seems to be safe and effective in the resection of HGGs, allowing a high rate of gross total removal of contrast enhanced areas.
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