ArticleBeilstein journal of organic chemistry2017
Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research.
Article in Beilstein journal of organic chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Modelling the prebiotic origins of regulation and agency in evolving protocell ecologies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Aminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity.RSC advances · 2021Article
- Femtoplankton: What's New?Viruses · 2020Review
- Biological phase separation: cell biology meets biophysics.Biophysical reviews · 2020Review
- The Construction of Biological 'Inter-Identity' as the Outcome of a Complex Process of Protocell Development in Prebiotic Evolution.Frontiers in physiology · 2020Article
- Toward long-lasting artificial cells that better mimic natural living cells.Emerging topics in life sciences · 2019Article
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Authors and funding
3 authors.
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Abstract
Conceiving the process of biogenesis as the evolutionary development of highly dynamic and integrated protocell populations provides the most appropriate framework to address the difficult problem of how prebiotic chemistry bridged the gap to full-fledged living organisms on the early Earth. In this contribution we briefly discuss the implications of taking dynamic, functionally integrated protocell systems (rather than complex reaction networks in bulk solution, sets of artificially evolvable replicating molecules, or even these same replicating molecules encapsulated in passive compartments) as the proper units of prebiotic evolution. We highlight, in particular, how the organisational features of those chemically active and reactive protocells, at different stages of the process, would strongly influence their corresponding evolutionary capacities. As a result of our analysis, we suggest three experimental challenges aimed at constructing protocell systems made of a diversity of functionally coupled components and, thereby, at characterizing more precisely the type of prebiotic evolutionary dynamics that such protocells could engage in.
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