ReviewBeilstein journal of organic chemistry2017
Synthesis of oligonucleotides on a soluble support.
Review in Beilstein journal of organic chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Biosensing device based on optical waveguide spectrometry with fluorescent solvatochromic beads for label-free tracking of avidin-biotin interaction.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- From liquid-phase synthesis to chemical ligation: preparation of oligonucleotides and their backbone analogs in solution.Nucleic acids research · 2025Review
- Selective Acetalization in Pyridine: A Sustainable 5'-Organic letters · 2025Article
- Nucleic acid joining enzymes: biological functions and synthetic applications beyond DNA.The Biochemical journal · 2025Review
- Nonaqueous Oxidation in DNA Microarray Synthesis Improves the Oligonucleotide Quality and Preserves Surface Integrity on Gold and Indium Tin Oxide Substrates.Analytical chemistry · 2024Article
- Stereo-Controlled Liquid Phase Synthesis of Phosphorothioate Oligonucleotides on a Soluble Support.The Journal of organic chemistry · 2023Article
- Article
- Modified Nucleotides for Chemical and Enzymatic Synthesis of Therapeutic RNA.Current medicinal chemistry · 2023Article
- Post-genomic platform for development of oligonucleotide vaccines against RNA viruses: diamond cuts diamond.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Article
- Solution-phase synthesis of oligodeoxyribonucleotides using theRSC advances · 2021Article
- Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support.RSC advances · 2021Article
- Synthesis of a Fluorescent Solvatochromic Resin Using Suzuki-Miyaura Cross-Coupling and Its Optical Waveguide Spectra to Measure the Solvent Polarity on the Surface.Materials (Basel, Switzerland) · 2020Article
- Scalable One-Pot-Liquid-Phase Oligonucleotide Synthesis for Model Network Hydrogels.Journal of the American Chemical Society · 2020Article
- Advances in intracellular delivery through supramolecular self-assembly of oligonucleotides and peptides.Theranostics · 2019Review
- Incorporation of Sensitive Ester and Chloropurine Groups into Oligodeoxynucleotides through Solid Phase Synthesis.ChemistrySelect · 2018Article
- Preparation of trinucleotide phosphoramidites as synthons for the synthesis of gene libraries.Beilstein journal of organic chemistry · 2018Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oligonucleotides are usually prepared in lab scale on a solid support with the aid of a fully automated synthesizer. Scaling up of the equipment has allowed industrial synthesis up to kilogram scale. In spite of this, solution-phase synthesis has received continuous interest, on one hand as a technique that could enable synthesis of even larger amounts and, on the other hand, as a gram scale laboratory synthesis without any special equipment. The synthesis on a soluble support has been regarded as an approach that could combine the advantageous features of both the solution and solid-phase syntheses. The critical step of this approach is the separation of the support-anchored oligonucleotide chain from the monomeric building block and other small molecular reagents and byproducts after each coupling, oxidation and deprotection step. The techniques applied so far include precipitation, extraction, chromatography and nanofiltration. As regards coupling, all conventional chemistries, viz. phosphoramidite,
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