Evidence map›Paper›PMID 28781697›Full record

ArticleBeilstein journal of organic chemistry2017

BODIPY-based fluorescent liposomes with sesquiterpene lactone trilobolide.

Ludmila Škorpilová, Silvie Rimpelová, Michal Jurášek, Miloš Buděšínský, Jana Lokajová, Roman Effenberg, Petr Slepička, Tomáš Ruml, Eva Kmoníčková, Pavel B Drašar and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Beilstein journal of organic chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Ludmila ŠkorpilováDepartment of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Silvie RimpelováDepartment of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Michal JurášekDepartment of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Miloš BuděšínskýInstitute of Organic Chemistry and Biochemistry, ASCR, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
Jana LokajováInstitute of Organic Chemistry and Biochemistry, ASCR, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
Roman EffenbergDepartment of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Petr SlepičkaDepartment of Solid State Engineering, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Tomáš RumlDepartment of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Eva KmoníčkováInstitute of Experimental Medicine, ASCR, Vídeňská 1083, 142 20 Prague 4, Czech Republic.
Pavel B DrašarDepartment of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Zdeněk WimmerDepartment of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
University of Chemistry and Technology, Prague · CZCzech Academy of Sciences, Institute of Organic Chemistry and Biochemistry · CZInstitute of Microbiology · BY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Like thapsigargin, which is undergoing clinical trials, trilobolide is a natural product with promising anticancer and anti-inflammatory properties. Similar to thapsigargin, it has limited aqueous solubility that strongly reduces its potential medicinal applications. The targeted delivery of hydrophobic drugs can be achieved using liposome-based carriers. Therefore, we designed a traceable liposomal drug delivery system for trilobolide. The fluorescent green-emitting dye BODIPY, cholesterol and trilobolide were used to create construct

Indexed as

BODIPY conjugatescancer targetingdrug deliveryliposomesnatural compoundssesquiterpene lactone trilobolide

Identifiers

PMID28781697
PMCPMC5530629
OpenAlexW2731255604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.